Phylogenetic analysis of the full-length SARS-CoV sequences: Evidence for phylogenetic discordance in three genomic regions

G. Magiorkinis, E. Magiorkinis, D. Paraskevis, A.-M. Vandamme, M. Van Ranst, V. Moulton, A. Hatzakiu

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The origin of the severe acute respiratory syndrome-coronavirus (SARS-CoV) remains unclear. Evidence based on Bayesian scanning plots and phylogenetic analysis using maximum likelihood (ML) and Bayesian methods indicates that SARS-CoV, for the largest part of the genome (~80%), is more closely related to Group II coronaviruses sequences, whereas in three regions in the ORF1ab gene it shows no apparent similarity to any of the previously characterized groups of coronaviruses. There is discordant phylogenetic clustering of SARS-CoV and coronaviruses sequences, throughout the genome, compatible with either ancient recombination events or altered evolutionary rates in different lineages, or a combination of both.
Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalJournal of Medical Virology
Issue number3
Publication statusPublished - Nov 2004

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