Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 632-639 |
| Number of pages | 8 |
| Journal | Nature Genetics |
| Volume | 47 |
| Issue number | 6 |
| Early online date | 11 May 2015 |
| DOIs | |
| Publication status | Published - 1 Jun 2015 |
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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events. / Wong, Vanessa K.; Baker, Stephen; Pickard, Derek J.; Parkhill, Julian; Page, Andrew J.; Feasey, Nicholas A.; Kingsley, Robert A.; Thomson, Nicholas R.; Keane, Jacqueline A.; Weill, François-Xavier; Edwards, David J.; Hawkey, Jane; Harris, Simon R.; Mather, Alison E.; Cain, Amy K.; Hadfield, James; Hart, Peter J.; Thieu, Nga Tran Vu; Klemm, Elizabeth J.; Glinos, Dafni A.; Breiman, Robert F.; Watson, Conall H.; Kariuki, Samuel; Gordon, Melita A.; Heyderman, Robert S.; Okoro, Chinyere; Jacobs, Jan; Lunguya, Octavie; Edmunds, W. John; Msefula, Chisomo; Chabalgoity, Jose A.; Kama, Mike; Jenkins, Kylie; Dutta, Shanta; Marks, Florian; Campos, Josefina; Thompson, Corinne; Obaro, Stephen; MacLennan, Calman A.; Dolecek, Christiane; Keddy, Karen H.; Smith, Anthony M.; Parry, Christopher M.; Karkey, Abhilasha; Mulholland, E. Kim; Campbell, James I.; Dongol, Sabina; Basnyat, Buddha; Dufour, Muriel; Bandaranayake, Don; Naseri, Take Toleafoa; Singh, Shalini Pravin; Hatta, Mochammad; Newton, Paul; Onsare, Robert S.; Isaia, Lupeoletalalei; Dance, David; Davong, Viengmon; Thwaites, Guy; Wijedoru, Lalith; Crump, John A.; De Pinna, Elizabeth; Nair, Satheesh; Nilles, Eric J.; Thanh, Duy Pham; Turner, Paul; Soeng, Sona; Valcanis, Mary; Powling, Joan; Dimovski, Karolina; Hogg, Geoff; Farrar, Jeremy; Holt, Kathryn E.; Dougan, Gordon.
In: Nature Genetics, Vol. 47, No. 6, 01.06.2015, p. 632-639.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
AU - Wong, Vanessa K.
AU - Baker, Stephen
AU - Pickard, Derek J.
AU - Parkhill, Julian
AU - Page, Andrew J.
AU - Feasey, Nicholas A.
AU - Kingsley, Robert A.
AU - Thomson, Nicholas R.
AU - Keane, Jacqueline A.
AU - Weill, François-Xavier
AU - Edwards, David J.
AU - Hawkey, Jane
AU - Harris, Simon R.
AU - Mather, Alison E.
AU - Cain, Amy K.
AU - Hadfield, James
AU - Hart, Peter J.
AU - Thieu, Nga Tran Vu
AU - Klemm, Elizabeth J.
AU - Glinos, Dafni A.
AU - Breiman, Robert F.
AU - Watson, Conall H.
AU - Kariuki, Samuel
AU - Gordon, Melita A.
AU - Heyderman, Robert S.
AU - Okoro, Chinyere
AU - Jacobs, Jan
AU - Lunguya, Octavie
AU - Edmunds, W. John
AU - Msefula, Chisomo
AU - Chabalgoity, Jose A.
AU - Kama, Mike
AU - Jenkins, Kylie
AU - Dutta, Shanta
AU - Marks, Florian
AU - Campos, Josefina
AU - Thompson, Corinne
AU - Obaro, Stephen
AU - MacLennan, Calman A.
AU - Dolecek, Christiane
AU - Keddy, Karen H.
AU - Smith, Anthony M.
AU - Parry, Christopher M.
AU - Karkey, Abhilasha
AU - Mulholland, E. Kim
AU - Campbell, James I.
AU - Dongol, Sabina
AU - Basnyat, Buddha
AU - Dufour, Muriel
AU - Bandaranayake, Don
AU - Naseri, Take Toleafoa
AU - Singh, Shalini Pravin
AU - Hatta, Mochammad
AU - Newton, Paul
AU - Onsare, Robert S.
AU - Isaia, Lupeoletalalei
AU - Dance, David
AU - Davong, Viengmon
AU - Thwaites, Guy
AU - Wijedoru, Lalith
AU - Crump, John A.
AU - De Pinna, Elizabeth
AU - Nair, Satheesh
AU - Nilles, Eric J.
AU - Thanh, Duy Pham
AU - Turner, Paul
AU - Soeng, Sona
AU - Valcanis, Mary
AU - Powling, Joan
AU - Dimovski, Karolina
AU - Hogg, Geoff
AU - Farrar, Jeremy
AU - Holt, Kathryn E.
AU - Dougan, Gordon
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.
AB - The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.
U2 - 10.1038/ng.3281
DO - 10.1038/ng.3281
M3 - Article
VL - 47
SP - 632
EP - 639
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 6
ER -