Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Yen-Ling Low; James I. Taylor; Philip B. Grace; Angela A. Mulligan; Ailsa A. Welch; Serena Scollen; Alison M. Dunning; Robert N. Luben; Kay-Tee Khaw; Nick E. Day; Nick J. Wareham; Sheila A. Bingham

doi:10.1207/s15327914nc5601_5

Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Yen-Ling Low, James I. Taylor, Philip B. Grace, Angela A. Mulligan, Ailsa A. Welch, Serena Scollen, Alison M. Dunning, Robert N. Luben, Kay-Tee Khaw, Nick E. Day, Nick J. Wareham, Sheila A. Bingham

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Nutrition and Cancer
Volume	56
Issue number	1
DOIs	https://doi.org/10.1207/s15327914nc5601_5
Publication status	Published - 2006

Keywords

Aged
Biological Markers
Diet
Genotype
Humans
Male
Middle Aged
Odds Ratio
Phytoestrogens
Polymorphism, Single Nucleotide
Prospective Studies
Prostatic Neoplasms
Risk Factors
United States

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1207/s15327914nc5601_5

Cite this

Low, Y-L., Taylor, J. I., Grace, P. B., Mulligan, A. A., Welch, A. A., Scollen, S., Dunning, A. M., Luben, R. N., Khaw, K-T., Day, N. E., Wareham, N. J., & Bingham, S. A. (2006). Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutrition and Cancer, 56(1), 31-39. https://doi.org/10.1207/s15327914nc5601_5

Low, Yen-Ling ; Taylor, James I. ; Grace, Philip B. ; Mulligan, Angela A. ; Welch, Ailsa A. ; Scollen, Serena ; Dunning, Alison M. ; Luben, Robert N. ; Khaw, Kay-Tee ; Day, Nick E. ; Wareham, Nick J. ; Bingham, Sheila A. / Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. In: Nutrition and Cancer. 2006 ; Vol. 56, No. 1. pp. 31-39.

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abstract = "Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P ",

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Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. / Low, Yen-Ling; Taylor, James I.; Grace, Philip B.; Mulligan, Angela A.; Welch, Ailsa A.; Scollen, Serena; Dunning, Alison M.; Luben, Robert N.; Khaw, Kay-Tee; Day, Nick E.; Wareham, Nick J.; Bingham, Sheila A.

In: Nutrition and Cancer, Vol. 56, No. 1, 2006, p. 31-39.

Research output: Contribution to journal › Article › peer-review

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