Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Yen-Ling Low, James I Taylor, Philip B Grace, Angela A Mulligan, Ailsa A Welch, Serena Scollen, Alison M Dunning, Robert N Luben, Kay-Tee Khaw, Nick E Day, Nick J Wareham, Sheila A Bingham

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Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P
Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalNutrition and Cancer
Volume56
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • Aged
  • Biological Markers
  • Diet
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Phytoestrogens
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Prostatic Neoplasms
  • Risk Factors
  • United States

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