Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Yen-Ling Low; James I. Taylor; Philip B. Grace; Angela A. Mulligan; Ailsa A. Welch; Serena Scollen; Alison M. Dunning; Robert N. Luben; Kay-Tee Khaw; Nick E. Day; Nick J. Wareham; Sheila A. Bingham

doi:10.1207/s15327914nc5601_5

Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Yen-Ling Low
, James I. Taylor
, Philip B. Grace
, Angela A. Mulligan
, Ailsa A. Welch
, Serena Scollen
, Alison M. Dunning
, Robert N. Luben
, Kay-Tee Khaw
, Nick E. Day
, Nick J. Wareham
, Sheila A. Bingham

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Nutrition and Cancer
Volume	56
Issue number	1
DOIs	https://doi.org/10.1207/s15327914nc5601_5
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Biological Markers
Diet
Genotype
Humans
Male
Middle Aged
Odds Ratio
Phytoestrogens
Polymorphism, Single Nucleotide
Prospective Studies
Prostatic Neoplasms
Risk Factors
United States

Access to Document

10.1207/s15327914nc5601_5

Cite this

Low, Y.-L., Taylor, J. I., Grace, P. B., Mulligan, A. A., Welch, A. A., Scollen, S., Dunning, A. M., Luben, R. N., Khaw, K.-T., Day, N. E., Wareham, N. J., & Bingham, S. A. (2006). Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutrition and Cancer, 56(1), 31-39. https://doi.org/10.1207/s15327914nc5601_5

@article{fd622af43b2949c5bfd4e448e48c0c70,

title = "Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk",

abstract = "Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P ",

keywords = "Aged, Biological Markers, Diet, Genotype, Humans, Male, Middle Aged, Odds Ratio, Phytoestrogens, Polymorphism, Single Nucleotide, Prospective Studies, Prostatic Neoplasms, Risk Factors, United States",

author = "Yen-Ling Low and Taylor, \{James I.\} and Grace, \{Philip B.\} and Mulligan, \{Angela A.\} and Welch, \{Ailsa A.\} and Serena Scollen and Dunning, \{Alison M.\} and Luben, \{Robert N.\} and Kay-Tee Khaw and Day, \{Nick E.\} and Wareham, \{Nick J.\} and Bingham, \{Sheila A.\}",

year = "2006",

doi = "10.1207/s15327914nc5601\_5",

language = "English",

volume = "56",

pages = "31--39",

journal = "Nutrition and Cancer",

issn = "1532-7914",

publisher = "Routledge",

number = "1",

}

TY - JOUR

T1 - Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

AU - Low, Yen-Ling

AU - Taylor, James I.

AU - Grace, Philip B.

AU - Mulligan, Angela A.

AU - Welch, Ailsa A.

AU - Scollen, Serena

AU - Dunning, Alison M.

AU - Luben, Robert N.

AU - Khaw, Kay-Tee

AU - Day, Nick E.

AU - Wareham, Nick J.

AU - Bingham, Sheila A.

PY - 2006

Y1 - 2006

N2 - Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

AB - Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

KW - Aged

KW - Biological Markers

KW - Diet

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Phytoestrogens

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Prostatic Neoplasms

KW - Risk Factors

KW - United States

U2 - 10.1207/s15327914nc5601_5

DO - 10.1207/s15327914nc5601_5

M3 - Article

C2 - 17176215

SN - 1532-7914

VL - 56

SP - 31

EP - 39

JO - Nutrition and Cancer

JF - Nutrition and Cancer

IS - 1

ER -