TY - JOUR
T1 - Phytol: A review of biomedical activities
AU - Islam, Muhammad Torequl
AU - Ali, Eunüs S.
AU - Uddin, Shaikh J.
AU - Shaw, Subrata
AU - Islam, Md Amirul
AU - Ahmed, Md Iqbal
AU - Chandra Shill, Manik
AU - Karmakar, Utpal Kumar
AU - Yarla, Nagendra Sastry
AU - Khan, Ishaq N.
AU - Billah, Md Morsaline
AU - Pieczynska, Magdalena D.
AU - Zengin, Gokhan
AU - Malainer, Clemens
AU - Nicoletti, Ferdinando
AU - Gulei, Diana
AU - Berindan-Neagoe, Ioana
AU - Apostolov, Apostol
AU - Banach, Maciej
AU - Yeung, Andy W. K.
AU - El-Demerdash, Amr
AU - Xiao, Jianbo
AU - Dey, Prasanta
AU - Yele, Santosh
AU - Jóźwik, Artur
AU - Strzałkowska, Nina
AU - Marchewka, Joanna
AU - Rengasamy, Kannan R. R.
AU - Horbańczuk, Jarosław
AU - Kamal, Mohammad Amjad
AU - Mubarak, Mohammad S.
AU - Mishra, Siddhartha K.
AU - Shilpi, Jamil A.
AU - Atanasov, Atanas G.
N1 - Funding Information:
AGA acknowledges the support by the Polish KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal—Safe Food,” decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015 .
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
AB - Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
KW - Biological activities
KW - Phytanic acid
KW - Phytol
KW - Phytol metabolites
KW - Plant-derived compounds
UR - http://www.scopus.com/inward/record.url?scp=85052092268&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2018.08.032
DO - 10.1016/j.fct.2018.08.032
M3 - Article
C2 - 30130593
AN - SCOPUS:85052092268
VL - 121
SP - 82
EP - 94
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
ER -