Projects per year
Abstract
The synthesis of pillar[5]arene-based glycoclusters has been readily achieved by CuAAC conjugations of azido- and alkyne-functionalized precursors. The lectin binding properties of the resulting glycosylated multivalent ligands have been studied by at least two complementary techniques in order to provide a good understanding. Three lectins were selected from bacterial pathogens based on their potential therapeutic applications as anti-adhesives, namely LecA and LecB from Pseudomonas aeruginosa and BambL from Burkholderia ambifaria. As a general trend, multivalency improved the binding to lectins and a higher affinity can be obtained by increasing to a certain limit the length of the spacer arm between the carbohydrate subunits and the central macrocyclic core.
Original language | English |
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Pages (from-to) | 2955-2963 |
Number of pages | 9 |
Journal | Chemistry - A European Journal |
Volume | 22 |
Issue number | 9 |
Early online date | 4 Feb 2016 |
DOIs | |
Publication status | Published - 24 Feb 2016 |
Projects
- 1 Finished
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Can topology of multivalent ligands induce selectivity among lectins?
Matthews, S. & Vidal (Lyon Uni), S.
1/02/10 → 31/01/13
Project: Research