Planar chiral palladacycle precatalysts for asymmetric synthesis

Ross A. Arthurs; David L. Hughes; Christopher J. Richards

doi:10.1039/d0ob01331e

Planar chiral palladacycle precatalysts for asymmetric synthesis

Ross A. Arthurs, David L. Hughes, Christopher J. Richards

Chemistry of Materials and Catalysis

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Abstract

Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.

Original language	English
Pages (from-to)	5466-5472
Number of pages	7
Journal	Organic & Biomolecular Chemistry
Volume	18
Issue number	28
Early online date	2 Jul 2020
DOIs	https://doi.org/10.1039/d0ob01331e
Publication status	Published - 28 Jul 2020

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10.1039/d0ob01331eLicence: CC BY-NC

Published_VersionFinal published version, 1.05 MBLicence: CC BY-NC

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abstract = "Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.",

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AU - Richards, Christopher J.

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N2 - Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.

AB - Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.

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ER -

Planar chiral palladacycle precatalysts for asymmetric synthesis

Abstract

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Chris Richards

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Planar chiral palladacycle precatalysts for asymmetric synthesis

Abstract

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Chris Richards

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