Abstract
A new copper catalysed desymmetrisation reaction of bisalkynyl ferrocenecarboxylic acids results in the first asymmetric synthesis of planar chiral pseudo-isocoumarins in up to 64 % enantiomeric excess and up to 99 % yield. The absolute configuration of the chiral heterocycles is proven by chemical correlation and circular dichroism spectroscopy, opening the way for the rational extension of this method to produce bioactive isocoumarin-fused ferrocene derivatives.
Original language | English |
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Article number | e202100841 |
Journal | European Journal of Inorganic Chemistry |
Volume | 2022 |
Issue number | 12 |
Early online date | 7 Apr 2022 |
DOIs | |
Publication status | Published - 27 Apr 2022 |
Keywords
- Asymmetric catalysis
- Asymmetric synthesis
- Chirality
- Circular dichroism
- Metallocenes