Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population

Cinzia Papadia, Paul Kelly, Saverio Caini, Gino Roberto Corazza, Tamara Shawa, Angelo Franzè, Alastair Forbes, Antonio Di Sabatino

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39 Citations (Scopus)


Studies have shown that the circulating citrulline concentration is decreased in patients with proximal small bowel villous atrophy from coeliac disease and more so in patients with extensive damage to the intestinal mucosa, but there have been few data on HIV enteritis and tropical enteropathy (TE). Our primary aim was to correlate serum citrulline with the degree of reduction of the enterocyte mass in HIV-infected patients with TE.
Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalClinical Nutrition
Issue number6
Publication statusPublished - Dec 2010


  • Adult
  • Atrophy
  • Biological Markers
  • Citrulline
  • Enterocytes
  • Female
  • HIV
  • HIV Infections
  • Humans
  • Intestinal Mucosa
  • Intestine, Small
  • Male
  • Middle Aged
  • Sprue, Tropical

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