Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects

Susan J. van Dijk; Edith J. M. Feskens; A. Geert Heidema; Marieke B. Bos; Ondine van de Rest; Johanna M. Geleijnse; Lisette C. P. G. M. de Groot; Michael Müller; Lydia A. Afman

doi:10.1371/journal.pone.0014422

Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects

Susan J. van Dijk, Edith J. M. Feskens, A. Geert Heidema, Marieke B. Bos, Ondine van de Rest, Johanna M. Geleijnse, Lisette C. P. G. M. de Groot, Michael Müller, Lydia A. Afman

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.

Original language	English
Article number	e14422
Journal	PLoS One
Volume	5
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0014422
Publication status	Published - 23 Dec 2010

Keywords

Adult
Aged
Biological Markers
Blood Proteins
Body Mass Index
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Female
Humans
Insulin
Male
Middle Aged
Overweight
Phenotype
Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0014422Licence: CC BY

Cite this

@article{8261eab7eb734176af2cbeb5f945109c,

title = "Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects",

abstract = "Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.",

keywords = "Adult, Aged, Biological Markers, Blood Proteins, Body Mass Index, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Male, Middle Aged, Overweight, Phenotype, Proteins",

author = "{van Dijk}, {Susan J.} and Feskens, {Edith J. M.} and Heidema, {A. Geert} and Bos, {Marieke B.} and {van de Rest}, Ondine and Geleijnse, {Johanna M.} and {de Groot}, {Lisette C. P. G. M.} and Michael M{\"u}ller and Afman, {Lydia A.}",

note = "{\textcopyright} 2010 van Dijk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2010",

month = dec,

day = "23",

doi = "10.1371/journal.pone.0014422",

language = "English",

volume = "5",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

}

TY - JOUR

T1 - Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects

AU - van Dijk, Susan J.

AU - Feskens, Edith J. M.

AU - Heidema, A. Geert

AU - Bos, Marieke B.

AU - van de Rest, Ondine

AU - Geleijnse, Johanna M.

AU - de Groot, Lisette C. P. G. M.

AU - Müller, Michael

AU - Afman, Lydia A.

N1 - © 2010 van Dijk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2010/12/23

Y1 - 2010/12/23

N2 - Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.

AB - Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.

KW - Adult

KW - Aged

KW - Biological Markers

KW - Blood Proteins

KW - Body Mass Index

KW - Cardiovascular Diseases

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Overweight

KW - Phenotype

KW - Proteins

U2 - 10.1371/journal.pone.0014422

DO - 10.1371/journal.pone.0014422

M3 - Article

C2 - 21203453

VL - 5

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e14422

ER -