Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects

Susan J. van Dijk, Edith J. M. Feskens, A. Geert Heidema, Marieke B. Bos, Ondine van de Rest, Johanna M. Geleijnse, Lisette C. P. G. M. de Groot, Michael Müller, Lydia A. Afman

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16 Citations (Scopus)


Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.
Original languageEnglish
Article numbere14422
JournalPLoS One
Issue number12
Publication statusPublished - 23 Dec 2010


  • Adult
  • Aged
  • Biological Markers
  • Blood Proteins
  • Body Mass Index
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Female
  • Humans
  • Insulin
  • Male
  • Middle Aged
  • Overweight
  • Phenotype
  • Proteins

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