TY - JOUR
T1 - Plasma vitamin C concentrations and risk of incident respiratory diseases and mortality in the European Prospective Investigation into Cancer-Norfolk Cohort
AU - Myint, Phyo Kyaw
AU - Wilson, Andrew M.
AU - Clark, Allan B.
AU - Luben, Robert N.
AU - Wareham, Nicholas J.
AU - Khaw, Kay-Tee
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background/Objectives: Cancerous and non-cancerous respiratory diseases are common and contribute significantly to global disease burden. We aim to quantify the association between plasma vitamin C concentrations as an indicator of high fruit and vegetable consumption and the risk of incident respiratory diseases and associated mortality in a general population. Subjects/Methods: Nineteen thousand three hundred and fifty-seven men and women aged 40–79 years without prevalent respiratory diseases at the baseline (1993–1997) and participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk study in the United Kingdom were followed through March 2015 for both incidence and mortality from respiratory diseases. Results: There were a total of 3914 incident events and 407 deaths due to any respiratory diseases (excluding lung cancers), 367 incident lung cancers and 280 lung cancer deaths during the follow-up (total person-years >300,000 years). Cox's proportional hazards models showed that persons in the top quartiles of baseline plasma vitamin C concentrations had a 43% lower risk of lung cancer (hazard ratio (HR) 0.57; 95% confidence interval (CI): 0.41–0.81) than did those in the bottom quartile, independently of potential confounders. The results are similar for any non-cancerous respiratory diseases (HR 0.85; 0.77–0.95), including chronic respiratory diseases (HR 0.81; 0.69–0.96) and pneumonia (HR 0.70; 0.59–0.83). The corresponding values for mortality were 0.54 (0.35–0.81), 0.81 (0.59–1.12), 0.85 (0.44–1.66) and 0.61 (0.37–1.01), respectively. Confining analyses to non-smokers showed 42% and 53% risk reduction of non-smoking-related lung cancer incidence and death. Conclusions: Higher levels of vitamin C concentrations as a marker of high fruit and vegetable consumption reduces the risk of cancerous and non-cancerous respiratory illnesses including non-smoking-related cancer incidence and deaths.
AB - Background/Objectives: Cancerous and non-cancerous respiratory diseases are common and contribute significantly to global disease burden. We aim to quantify the association between plasma vitamin C concentrations as an indicator of high fruit and vegetable consumption and the risk of incident respiratory diseases and associated mortality in a general population. Subjects/Methods: Nineteen thousand three hundred and fifty-seven men and women aged 40–79 years without prevalent respiratory diseases at the baseline (1993–1997) and participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk study in the United Kingdom were followed through March 2015 for both incidence and mortality from respiratory diseases. Results: There were a total of 3914 incident events and 407 deaths due to any respiratory diseases (excluding lung cancers), 367 incident lung cancers and 280 lung cancer deaths during the follow-up (total person-years >300,000 years). Cox's proportional hazards models showed that persons in the top quartiles of baseline plasma vitamin C concentrations had a 43% lower risk of lung cancer (hazard ratio (HR) 0.57; 95% confidence interval (CI): 0.41–0.81) than did those in the bottom quartile, independently of potential confounders. The results are similar for any non-cancerous respiratory diseases (HR 0.85; 0.77–0.95), including chronic respiratory diseases (HR 0.81; 0.69–0.96) and pneumonia (HR 0.70; 0.59–0.83). The corresponding values for mortality were 0.54 (0.35–0.81), 0.81 (0.59–1.12), 0.85 (0.44–1.66) and 0.61 (0.37–1.01), respectively. Confining analyses to non-smokers showed 42% and 53% risk reduction of non-smoking-related lung cancer incidence and death. Conclusions: Higher levels of vitamin C concentrations as a marker of high fruit and vegetable consumption reduces the risk of cancerous and non-cancerous respiratory illnesses including non-smoking-related cancer incidence and deaths.
UR - http://www.scopus.com/inward/record.url?scp=85060954989&partnerID=8YFLogxK
U2 - 10.1038/s41430-019-0393-1
DO - 10.1038/s41430-019-0393-1
M3 - Article
SN - 0954-3007
VL - 73
SP - 1492
EP - 1500
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 11
ER -