Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes

Richard A Anderson; Gethin R Ellis; L Marc Evans; Keith Morris; Yuri Y Chirkov; John D Horowitz; Simon K Jackson; Alan Rees; Malcolm J Lewis; Michael P Frenneaux

doi:10.3132/dvdr.2005.015

Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes

Richard A Anderson, Gethin R Ellis, L Marc Evans, Keith Morris, Yuri Y Chirkov, John D Horowitz, Simon K Jackson, Alan Rees, Malcolm J Lewis, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Vascular responsiveness to exogenous nitrates in type 2 diabetes (T2DM) is attenuated in brachial and coronary vessels. We determined platelet responsiveness to nitric oxide (NO) in T2DM and control subjects. We examined whether the postprandial (PP) state affected platelet sensitivity to NO donors in T2DM patients and the extent of correlation between this and measures of oxidative stress, compared to changes in endothelial function. Twelve T2DM subjects were studied fasting and four hours after a test meal and compared with 15 healthy controls. We assessed the inhibitory effects of NO donors on adenosine 5'-diphosphate (ADP)-induced platelet aggregation. Oxidative stress was assessed by lipid-derived free radicals, ex vivo by electron paramagnetic resonance spectroscopy and markers of lipid peroxidation. Endothelial function was assessed by flow-mediated vasodilatation (FMD) of the brachial artery. Results are expressed as (mean +/- SEM). Fasting platelet aggregation was increased in diabetics versus controls (14.86 +/- 1.1 Ohms vs. 10.76 +/- 1.1 Ohms, p

Original language	English
Pages (from-to)	88-93
Number of pages	6
Journal	Diabetes & Vascular Disease Research
Volume	2
Issue number	2
DOIs	https://doi.org/10.3132/dvdr.2005.015
Publication status	Published - May 2005

Keywords

Adenosine Diphosphate
Adult
Aged
Blood Platelets
Brachial Artery
Diabetes Mellitus, Type 2
Fasting
Female
Free Radicals
Humans
Lipid Peroxidation
Male
Middle Aged
Nitrates
Nitric Oxide Donors
Nitroglycerin
Nitroprusside
Oxidative Stress
Platelet Aggregation
Postprandial Period
Time Factors
Vasodilation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3132/dvdr.2005.015

Cite this

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title = "Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes",

abstract = "Vascular responsiveness to exogenous nitrates in type 2 diabetes (T2DM) is attenuated in brachial and coronary vessels. We determined platelet responsiveness to nitric oxide (NO) in T2DM and control subjects. We examined whether the postprandial (PP) state affected platelet sensitivity to NO donors in T2DM patients and the extent of correlation between this and measures of oxidative stress, compared to changes in endothelial function. Twelve T2DM subjects were studied fasting and four hours after a test meal and compared with 15 healthy controls. We assessed the inhibitory effects of NO donors on adenosine 5'-diphosphate (ADP)-induced platelet aggregation. Oxidative stress was assessed by lipid-derived free radicals, ex vivo by electron paramagnetic resonance spectroscopy and markers of lipid peroxidation. Endothelial function was assessed by flow-mediated vasodilatation (FMD) of the brachial artery. Results are expressed as (mean +/- SEM). Fasting platelet aggregation was increased in diabetics versus controls (14.86 +/- 1.1 Ohms vs. 10.76 +/- 1.1 Ohms, p ",

keywords = "Adenosine Diphosphate, Adult, Aged, Blood Platelets, Brachial Artery, Diabetes Mellitus, Type 2, Fasting, Female, Free Radicals, Humans, Lipid Peroxidation, Male, Middle Aged, Nitrates, Nitric Oxide Donors, Nitroglycerin, Nitroprusside, Oxidative Stress, Platelet Aggregation, Postprandial Period, Time Factors, Vasodilation",

author = "Anderson, {Richard A} and Ellis, {Gethin R} and Evans, {L Marc} and Keith Morris and Chirkov, {Yuri Y} and Horowitz, {John D} and Jackson, {Simon K} and Alan Rees and Lewis, {Malcolm J} and Frenneaux, {Michael P}",

year = "2005",

month = may,

doi = "10.3132/dvdr.2005.015",

language = "English",

volume = "2",

pages = "88--93",

journal = "Diabetes & Vascular Disease Research",

issn = "1479-1641",

publisher = "Sage Publications",

number = "2",

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Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes. / Anderson, Richard A; Ellis, Gethin R; Evans, L Marc; Morris, Keith; Chirkov, Yuri Y; Horowitz, John D; Jackson, Simon K; Rees, Alan; Lewis, Malcolm J; Frenneaux, Michael P.

In: Diabetes & Vascular Disease Research, Vol. 2, No. 2, 05.2005, p. 88-93.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes

AU - Anderson, Richard A

AU - Ellis, Gethin R

AU - Evans, L Marc

AU - Morris, Keith

AU - Chirkov, Yuri Y

AU - Horowitz, John D

AU - Jackson, Simon K

AU - Rees, Alan

AU - Lewis, Malcolm J

AU - Frenneaux, Michael P

PY - 2005/5

Y1 - 2005/5

N2 - Vascular responsiveness to exogenous nitrates in type 2 diabetes (T2DM) is attenuated in brachial and coronary vessels. We determined platelet responsiveness to nitric oxide (NO) in T2DM and control subjects. We examined whether the postprandial (PP) state affected platelet sensitivity to NO donors in T2DM patients and the extent of correlation between this and measures of oxidative stress, compared to changes in endothelial function. Twelve T2DM subjects were studied fasting and four hours after a test meal and compared with 15 healthy controls. We assessed the inhibitory effects of NO donors on adenosine 5'-diphosphate (ADP)-induced platelet aggregation. Oxidative stress was assessed by lipid-derived free radicals, ex vivo by electron paramagnetic resonance spectroscopy and markers of lipid peroxidation. Endothelial function was assessed by flow-mediated vasodilatation (FMD) of the brachial artery. Results are expressed as (mean +/- SEM). Fasting platelet aggregation was increased in diabetics versus controls (14.86 +/- 1.1 Ohms vs. 10.76 +/- 1.1 Ohms, p

AB - Vascular responsiveness to exogenous nitrates in type 2 diabetes (T2DM) is attenuated in brachial and coronary vessels. We determined platelet responsiveness to nitric oxide (NO) in T2DM and control subjects. We examined whether the postprandial (PP) state affected platelet sensitivity to NO donors in T2DM patients and the extent of correlation between this and measures of oxidative stress, compared to changes in endothelial function. Twelve T2DM subjects were studied fasting and four hours after a test meal and compared with 15 healthy controls. We assessed the inhibitory effects of NO donors on adenosine 5'-diphosphate (ADP)-induced platelet aggregation. Oxidative stress was assessed by lipid-derived free radicals, ex vivo by electron paramagnetic resonance spectroscopy and markers of lipid peroxidation. Endothelial function was assessed by flow-mediated vasodilatation (FMD) of the brachial artery. Results are expressed as (mean +/- SEM). Fasting platelet aggregation was increased in diabetics versus controls (14.86 +/- 1.1 Ohms vs. 10.76 +/- 1.1 Ohms, p

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KW - Aged

KW - Blood Platelets

KW - Brachial Artery

KW - Diabetes Mellitus, Type 2

KW - Fasting

KW - Female

KW - Free Radicals

KW - Humans

KW - Lipid Peroxidation

KW - Male

KW - Middle Aged

KW - Nitrates

KW - Nitric Oxide Donors

KW - Nitroglycerin

KW - Nitroprusside

KW - Oxidative Stress

KW - Platelet Aggregation

KW - Postprandial Period

KW - Time Factors

KW - Vasodilation

U2 - 10.3132/dvdr.2005.015

DO - 10.3132/dvdr.2005.015

M3 - Article

C2 - 16305064

VL - 2

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EP - 93

JO - Diabetes & Vascular Disease Research

JF - Diabetes & Vascular Disease Research

SN - 1479-1641

IS - 2

ER -