Platinum and Gold Catalysis: à la Carte Hydroamination of Terminal Activated Allenes with Azoles

José Miguel Alonso, Maria Paz Munoz-Herranz

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Abstract

Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to get selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold-platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, important scaf-fold in medicinal and organometallic chemistry.
Original languageEnglish
Pages (from-to)7639-7644
JournalOrganic Letters
Volume21
Issue number18
Early online date3 Sep 2019
DOIs
Publication statusPublished - 20 Sep 2019

Keywords

  • allenes
  • azoles
  • bimetallic catalysis
  • gold
  • platinum

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