Polyisoprenylated Benzoylphloroglucinol Derivatives from Hypericum sampsonii

Zhi Yong Xiao, Qing Mu, Winnie Ka Po Shiu, Yi Han Zeng, Simon Gibbons

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64 Citations (Scopus)

Abstract

Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.
Original languageEnglish
Pages (from-to)1779-1782
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number11
DOIs
Publication statusPublished - 1 Nov 2007

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