Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia

S B Wharton; J P O'Callaghan; G M Savva; J A R Nicoll; F Matthews; J E Simpson; G Forster; P J Shaw; C Brayne; P G Ince; MRC Cognitive Function and Ageing Neuropathology Study Group

doi:10.1159/000217729

Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia

S B Wharton, J P O'Callaghan, G M Savva, J A R Nicoll, F Matthews, J E Simpson, G Forster, P J Shaw, C Brayne, P G Ince, MRC Cognitive Function and Ageing Neuropathology Study Group

Norwich Epidemiology Centre

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.

Original language	English
Pages (from-to)	465-473
Number of pages	9
Journal	Dementia and Geriatric Cognitive Disorders
Volume	27
Issue number	5
DOIs	https://doi.org/10.1159/000217729
Publication status	Published - 2009

Keywords

Aged
Aging
Alzheimer Disease
Amyloid beta-Peptides
Apolipoprotein E4
Astrocytes
Brain
Brain Chemistry
Cohort Studies
Dementia
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Glial Fibrillary Acidic Protein
Gliosis
Humans
Immunohistochemistry
Male

Access to Document

10.1159/000217729

Cite this

Wharton, S. B., O'Callaghan, J. P., Savva, G. M., Nicoll, J. A. R., Matthews, F., Simpson, J. E., Forster, G., Shaw, P. J., Brayne, C., Ince, P. G., & MRC Cognitive Function and Ageing Neuropathology Study Group (2009). Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia. Dementia and Geriatric Cognitive Disorders, 27(5), 465-473. https://doi.org/10.1159/000217729

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abstract = "The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.",

keywords = "Aged, Aging, Alzheimer Disease, Amyloid beta-Peptides, Apolipoprotein E4, Astrocytes, Brain, Brain Chemistry, Cohort Studies, Dementia, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Glial Fibrillary Acidic Protein, Gliosis, Humans, Immunohistochemistry, Male",

author = "Wharton, {S B} and O'Callaghan, {J P} and Savva, {G M} and Nicoll, {J A R} and F Matthews and Simpson, {J E} and G Forster and Shaw, {P J} and C Brayne and Ince, {P G} and {MRC Cognitive Function and Ageing Neuropathology Study Group}",

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doi = "10.1159/000217729",

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Wharton, SB, O'Callaghan, JP, Savva, GM, Nicoll, JAR, Matthews, F, Simpson, JE, Forster, G, Shaw, PJ, Brayne, C, Ince, PG & MRC Cognitive Function and Ageing Neuropathology Study Group 2009, 'Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia', Dementia and Geriatric Cognitive Disorders, vol. 27, no. 5, pp. 465-473. https://doi.org/10.1159/000217729

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T1 - Population variation in glial fibrillary acidic protein levels in brain ageing

T2 - relationship to Alzheimer-type pathology and dementia

AU - Wharton, S B

AU - O'Callaghan, J P

AU - Savva, G M

AU - Nicoll, J A R

AU - Matthews, F

AU - Simpson, J E

AU - Forster, G

AU - Shaw, P J

AU - Brayne, C

AU - Ince, P G

AU - MRC Cognitive Function and Ageing Neuropathology Study Group

PY - 2009

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N2 - The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.

AB - The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.

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KW - Aging

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Apolipoprotein E4

KW - Astrocytes

KW - Brain

KW - Brain Chemistry

KW - Cohort Studies

KW - Dementia

KW - Disease Progression

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Genotype

KW - Glial Fibrillary Acidic Protein

KW - Gliosis

KW - Humans

KW - Immunohistochemistry

KW - Male

U2 - 10.1159/000217729

DO - 10.1159/000217729

M3 - Article

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