Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia

MRC Cognitive Function and Ageing Neuropathology Study Group, S B Wharton, J P O'Callaghan, G M Savva, J A R Nicoll, F Matthews, J E Simpson, G Forster, P J Shaw, C Brayne, P G Ince

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.
Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Volume27
Issue number5
DOIs
Publication statusPublished - 2009

Keywords

  • Aged
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Astrocytes
  • Brain
  • Brain Chemistry
  • Cohort Studies
  • Dementia
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genotype
  • Glial Fibrillary Acidic Protein
  • Gliosis
  • Humans
  • Immunohistochemistry
  • Male

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