Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia

S B Wharton, J P O'Callaghan, G M Savva, J A R Nicoll, F Matthews, J E Simpson, G Forster, P J Shaw, C Brayne, P G Ince, MRC Cognitive Function and Ageing Neuropathology Study Group

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.
Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number5
Publication statusPublished - 2009


  • Aged
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Astrocytes
  • Brain
  • Brain Chemistry
  • Cohort Studies
  • Dementia
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genotype
  • Glial Fibrillary Acidic Protein
  • Gliosis
  • Humans
  • Immunohistochemistry
  • Male

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