Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia

S B Wharton, J P O'Callaghan, G M Savva, J A R Nicoll, F Matthews, J E Simpson, G Forster, P J Shaw, C Brayne, P G Ince, MRC Cognitive Function and Ageing Neuropathology Study Group

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood.
    Original languageEnglish
    Pages (from-to)465-473
    Number of pages9
    JournalDementia and Geriatric Cognitive Disorders
    Volume27
    Issue number5
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Aged
    • Aging
    • Alzheimer Disease
    • Amyloid beta-Peptides
    • Apolipoprotein E4
    • Astrocytes
    • Brain
    • Brain Chemistry
    • Cohort Studies
    • Dementia
    • Disease Progression
    • Enzyme-Linked Immunosorbent Assay
    • Female
    • Genotype
    • Glial Fibrillary Acidic Protein
    • Gliosis
    • Humans
    • Immunohistochemistry
    • Male

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