Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

J E Simpson; P G Ince; L J Haynes; R Theaker; C Gelsthorpe; L Baxter; G Forster; G L Lace; P J Shaw; F E Matthews; G M Savva; C Brayne; S B Wharton; MRC Cognitive Function and Ageing Neuropathology Study Group

doi:10.1111/j.1365-2990.2009.01030.x

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

J E Simpson, P G Ince, L J Haynes, R Theaker, C Gelsthorpe, L Baxter, G Forster, G L Lace, P J Shaw, F E Matthews, G M Savva, C Brayne, S B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology.

Original language	English
Pages (from-to)	25-40
Number of pages	16
Journal	Neuropathology and Applied Neurobiology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2990.2009.01030.x
Publication status	Published - Feb 2010

Keywords

Aged
Aging
Alzheimer Disease
Astrocytes
Blotting, Western
Brain
DNA Damage
DNA-Activated Protein Kinase
Deoxyguanosine
Histones
Humans
Immunohistochemistry
Neurons
Oxidative Stress

Access to Document

10.1111/j.1365-2990.2009.01030.x

Cite this

Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., Forster, G., Lace, G. L., Shaw, P. J., Matthews, F. E., Savva, G. M., Brayne, C., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2010). Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36(1), 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

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keywords = "Aged, Aging, Alzheimer Disease, Astrocytes, Blotting, Western, Brain, DNA Damage, DNA-Activated Protein Kinase, Deoxyguanosine, Histones, Humans, Immunohistochemistry, Neurons, Oxidative Stress",

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Simpson, JE, Ince, PG, Haynes, LJ, Theaker, R, Gelsthorpe, C, Baxter, L, Forster, G, Lace, GL, Shaw, PJ, Matthews, FE, Savva, GM, Brayne, C, Wharton, SB & MRC Cognitive Function and Ageing Neuropathology Study Group 2010, 'Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain', Neuropathology and Applied Neurobiology, vol. 36, no. 1, pp. 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

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AU - Ince, P G

AU - Haynes, L J

AU - Theaker, R

AU - Gelsthorpe, C

AU - Baxter, L

AU - Forster, G

AU - Lace, G L

AU - Shaw, P J

AU - Matthews, F E

AU - Savva, G M

AU - Brayne, C

AU - Wharton, S B

AU - MRC Cognitive Function and Ageing Neuropathology Study Group

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KW - Aging

KW - Alzheimer Disease

KW - Astrocytes

KW - Blotting, Western

KW - Brain

KW - DNA Damage

KW - DNA-Activated Protein Kinase

KW - Deoxyguanosine

KW - Histones

KW - Humans

KW - Immunohistochemistry

KW - Neurons

KW - Oxidative Stress

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