Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

J E Simpson, P G Ince, L J Haynes, R Theaker, C Gelsthorpe, L Baxter, G Forster, G L Lace, P J Shaw, F E Matthews, G M Savva, C Brayne, S B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group

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69 Citations (Scopus)

Abstract

Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology.
Original languageEnglish
Pages (from-to)25-40
Number of pages16
JournalNeuropathology and Applied Neurobiology
Volume36
Issue number1
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Aged
  • Aging
  • Alzheimer Disease
  • Astrocytes
  • Blotting, Western
  • Brain
  • DNA Damage
  • DNA-Activated Protein Kinase
  • Deoxyguanosine
  • Histones
  • Humans
  • Immunohistochemistry
  • Neurons
  • Oxidative Stress

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