TY - JOUR
T1 - Porphyrin self-assembled monolayers and photodynamic oxidation of tryptophan
AU - Chambrier, Isabelle
AU - Russell, David A.
AU - Brundish, Derek E.
AU - Love, William G.
AU - Jori, Giulio
AU - Magaraggia, M.
AU - Cook, Michael J.
PY - 2010
Y1 - 2010
N2 - The zinc and magnesium metalated derivatives of 5,5'-[12,12'-di(thiododecyloxy)-4,4'-phenyl)]-10,10',15,15',20,20'-hexakis(3,3',4,4',5,5'-hexakisdecyloxyphenyl)diporphyrin, 1b and 1c, have been synthesised and deposited to form self-assembled monolayer (SAM) films on the surface of gold-coated glass substrates. The SAM films have been characterized by RAIR spectroscopy and fluorescence spectroscopy. The potential for the porphyrin films to catalyze the oxidation of tryptophan within human serum albumin upon irradiation with white light has been demonstrated and attributed to the porphyrins acting as photosensitizers of oxygen to form oxidizing species.
AB - The zinc and magnesium metalated derivatives of 5,5'-[12,12'-di(thiododecyloxy)-4,4'-phenyl)]-10,10',15,15',20,20'-hexakis(3,3',4,4',5,5'-hexakisdecyloxyphenyl)diporphyrin, 1b and 1c, have been synthesised and deposited to form self-assembled monolayer (SAM) films on the surface of gold-coated glass substrates. The SAM films have been characterized by RAIR spectroscopy and fluorescence spectroscopy. The potential for the porphyrin films to catalyze the oxidation of tryptophan within human serum albumin upon irradiation with white light has been demonstrated and attributed to the porphyrins acting as photosensitizers of oxygen to form oxidizing species.
U2 - 10.1142/S1088424610001696
DO - 10.1142/S1088424610001696
M3 - Article
SN - 1088-4246
VL - 14
SP - 81
EP - 88
JO - Journal of Porphyrins and Phthalocyanines
JF - Journal of Porphyrins and Phthalocyanines
IS - 01
ER -