Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

Shiyi Cao; Yong Gan; Chao Wang; Max O. Bachmann; Shanbo Wei; Jie Gong; Yuchai Huang; Tiantian Wang; Liqing Li; Kai Lu; Heng Jiang; Yanhong Gong; Hongbin Xu; Xin Shen; Qingfeng Tian; Chuanzhu Lv; Fujian Song; Xiaoxv Yin; Zuxun Lu

doi:10.1038/s41467-020-19802-w

Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

Shiyi Cao, Yong Gan, Chao Wang, Max O. Bachmann, Shanbo Wei, Jie Gong, Yuchai Huang, Tiantian Wang, Liqing Li, Kai Lu, Heng Jiang, Yanhong Gong, Hongbin Xu, Xin Shen, Qingfeng Tian, Chuanzhu Lv, Fujian Song (Lead Author), Xiaoxv Yin, Zuxun Lu

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Abstract

Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.

Original language	English
Article number	5917
Journal	Nature Communications
Volume	11
DOIs	https://doi.org/10.1038/s41467-020-19802-w
Publication status	Published - 20 Nov 2020

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10.1038/s41467-020-19802-wLicence: CC BY

Published_Version Final published version, 9.02 MBLicence: CC BY

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title = "Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China",

abstract = "Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.",

author = "Shiyi Cao and Yong Gan and Chao Wang and Bachmann, {Max O.} and Shanbo Wei and Jie Gong and Yuchai Huang and Tiantian Wang and Liqing Li and Kai Lu and Heng Jiang and Yanhong Gong and Hongbin Xu and Xin Shen and Qingfeng Tian and Chuanzhu Lv and Fujian Song and Xiaoxv Yin and Zuxun Lu",

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doi = "10.1038/s41467-020-19802-w",

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AU - Cao, Shiyi

AU - Gan, Yong

AU - Wang, Chao

AU - Bachmann, Max O.

AU - Wei, Shanbo

AU - Gong, Jie

AU - Huang, Yuchai

AU - Wang, Tiantian

AU - Li, Liqing

AU - Lu, Kai

AU - Jiang, Heng

AU - Gong, Yanhong

AU - Xu, Hongbin

AU - Shen, Xin

AU - Tian, Qingfeng

AU - Lv, Chuanzhu

AU - Song, Fujian

AU - Yin, Xiaoxv

AU - Lu, Zuxun

PY - 2020/11/20

Y1 - 2020/11/20

N2 - Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.

AB - Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.

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Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

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Max Bachmann

Fujian Song

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Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

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Max Bachmann

Fujian Song

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