PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression

Heleen M de Vogel-van den Bosch, Meike Bünger, Philip J de Groot, Hanneke Bosch-Vermeulen, Guido J E J Hooiveld, Michael Müller

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61 Citations (Scopus)


The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'. An important receptor that mediates the effects of dietary lipids on gene expression is the peroxisome proliferator-activated receptor alpha (PPARalpha), which is abundantly expressed in enterocytes. In this study we examined the effects of acute nutritional activation of PPARalpha on expression of genes encoding intestinal barrier proteins. To this end we used triacylglycerols composed of identical fatty acids in combination with gene expression profiling in wild-type and PPARalpha-null mice. Treatment with the synthetic PPARalpha agonist WY14643 served as reference.
Original languageEnglish
Article number231
JournalBMC Genomics
Publication statusPublished - 19 May 2008


  • Animals
  • Biological Transport, Active
  • Cholesterol
  • Dietary Fats, Unsaturated
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Fatty Acids
  • Gastrointestinal Motility
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Intestinal Absorption
  • Intestine, Small
  • Male
  • Mice
  • Mice, Knockout
  • Oleic Acid
  • Oligonucleotide Array Sequence Analysis
  • Oxidation-Reduction
  • Oxidative Stress
  • PPAR alpha
  • Pyrimidines

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