TY - JOUR
T1 - Practical de-O-acylation reactions promoted by molecular sieves
AU - Kartha, K. P. Ravindranathan
AU - Mukhopadhyay, Balaram
AU - Field, Robert A.
N1 - Funding Information: MRC, EPSRC and the Weston Foundation.
PY - 2004/2/25
Y1 - 2004/2/25
N2 - Methanol dried extensively over molecular sieves, or methanol in combination with powdered molecular sieves, serves as a good acceptor for acyl transfer reactions. Several O-acetylated and O-benzoylated sugar derivatives were efficiently de-O-acylated using this approach. In the case of per-O-acetylated N-acetylglucosamine, selective anomeric deprotection could be effected in high yield.
AB - Methanol dried extensively over molecular sieves, or methanol in combination with powdered molecular sieves, serves as a good acceptor for acyl transfer reactions. Several O-acetylated and O-benzoylated sugar derivatives were efficiently de-O-acylated using this approach. In the case of per-O-acetylated N-acetylglucosamine, selective anomeric deprotection could be effected in high yield.
KW - Alcohols
KW - Deacetylation
KW - Molecular sieves
UR - http://www.scopus.com/inward/record.url?scp=0842309174&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2003.11.021
DO - 10.1016/j.carres.2003.11.021
M3 - Article
C2 - 15013413
AN - SCOPUS:0842309174
VL - 339
SP - 729
EP - 732
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
IS - 3
ER -