Practical synthesis of sugar monophosphonucleotides

W. A. Wlassoff, R. M. J. Finlay, C. J. Hamilton

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3 Citations (Scopus)


A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.
Original languageEnglish
Pages (from-to)2927-2934
Number of pages8
JournalSynthetic Communications
Issue number17
Publication statusPublished - 2007

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