Practical synthesis of sugar monophosphonucleotides

W. A. Wlassoff; R. M. J. Finlay; C. J. Hamilton

doi:10.1080/00397910701471543

Practical synthesis of sugar monophosphonucleotides

W. A. Wlassoff
, R. M. J. Finlay
, C. J. Hamilton

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.

Original language	English
Pages (from-to)	2927-2934
Number of pages	8
Journal	Synthetic Communications
Volume	37
Issue number	17
DOIs	https://doi.org/10.1080/00397910701471543
Publication status	Published - 2007

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10.1080/00397910701471543

Cite this

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title = "Practical synthesis of sugar monophosphonucleotides",

abstract = "A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.",

author = "Wlassoff, \{W. A.\} and Finlay, \{R. M. J.\} and Hamilton, \{C. J.\}",

year = "2007",

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T1 - Practical synthesis of sugar monophosphonucleotides

AU - Wlassoff, W. A.

AU - Finlay, R. M. J.

AU - Hamilton, C. J.

PY - 2007

Y1 - 2007

N2 - A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.

AB - A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.

U2 - 10.1080/00397910701471543

DO - 10.1080/00397910701471543

M3 - Article

SN - 0039-7911

VL - 37

SP - 2927

EP - 2934

JO - Synthetic Communications

JF - Synthetic Communications

IS - 17

ER -