Precious metal complexes of bis(pyridyl)allenes: Synthesis, catalytic and medicinal applications

Hanna K. Maliszewska, Carla Arnau del Valle, Ying Xia, María J. Marín, Zoë A. E. Waller, María Paz Muñoz

Research output: Contribution to journalArticlepeer-review

Abstract

The incorporation of donor-type substituents on the allene core opens up the possibility of coordination complexes in which the metal is bonded to the donor groups, with or without interaction with the double bond system. Despite the challenges in the synthesis of such allene-containing metal complexes, their unique 3D environments and dual functionality (allene and metal) could facilitate catalysis and interaction with chemical and biological systems. Bis(pyridyl)allenes are presented here as robust ligands for novel Pd(II), Pt(IV) and Au(III) complexes. Their synthesis, characterisation and first application as catalysts of benchmark reactions for Pd, Pt and Au are presented with interesting reactivity and selectivities. The complexes have also been probed as antimicrobial and anticancer agents with promising activities, and the first studies on their unusual interaction with several DNA structures will open new avenues for research in the area of metallodrugs with new mechanisms of action.
Original languageEnglish
Pages (from-to)16739-16750
Number of pages12
JournalDalton Transactions
Volume50
Issue number45
Early online date3 Nov 2021
DOIs
Publication statusPublished - 7 Dec 2021

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