Prenylated benzophenone peroxide derivatives from Hypericum sampsonii

Zhi Yong Xiao, Yi Han Zeng, Qing Mu, Winnie Ka Po Shiu, Simon Gibbons

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    41 Citations (Scopus)

    Abstract

    Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3.1.19,13.0 1,7]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.

    Original languageEnglish
    Pages (from-to)953-958
    Number of pages6
    JournalChemistry and Biodiversity
    Volume7
    Issue number4
    Early online date15 Apr 0201
    DOIs
    Publication statusPublished - Apr 2010

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