TY - JOUR
T1 - Prenylated benzophenone peroxide derivatives from Hypericum sampsonii
AU - Xiao, Zhi Yong
AU - Zeng, Yi Han
AU - Mu, Qing
AU - Shiu, Winnie Ka Po
AU - Gibbons, Simon
PY - 2010/4
Y1 - 2010/4
N2 - Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3.1.19,13.0 1,7]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.
AB - Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3.1.19,13.0 1,7]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.
UR - http://www.scopus.com/inward/record.url?scp=77951183944&partnerID=8YFLogxK
U2 - 10.1002/cbdv.200900247
DO - 10.1002/cbdv.200900247
M3 - Article
C2 - 20397228
AN - SCOPUS:77951183944
VL - 7
SP - 953
EP - 958
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
SN - 1612-1872
IS - 4
ER -