Prenylated benzophenone peroxide derivatives from Hypericum sampsonii

Zhi Yong Xiao, Yi Han Zeng, Qing Mu, Winnie Ka Po Shiu, Simon Gibbons

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40 Citations (Scopus)


Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[,13.0 1,7]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.

Original languageEnglish
Pages (from-to)953-958
Number of pages6
JournalChemistry and Biodiversity
Issue number4
Early online date15 Apr 0201
Publication statusPublished - Apr 2010

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