Preparation and Characterisation of Ultra-Fast Dissolving Orodispersible Films for Treating and Preventing Iodine Deficiency in the Paediatric Population

Cholpon Rustemkyzy, Peter Belton, Sheng Qi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
8 Downloads (Pure)

Abstract

Iodine deficiency is a public health problem that is easily prevented in many countries through having a salt iodization programme. However, the World Health Organisation (WHO) recommends that particular population groups including infants and young children have a higher daily iodine dose than adults, whilst also reducing salt consumption in their diet. Whilst many iodine supplements are available, swallowing tablet supplements is physically difficult for young children, thus there is a need for the development of novel iodine delivery systems for paediatric patients. In this study a novel, ultra-fast dissolving, nanofiber based orodispersible film iodine delivery system manufactured using an electrospinning technique was developed. The potassium iodate (KIO3) loaded poly (ethylene oxide) (PEO) fibre orodispersible films dissolve within seconds on wetting (applying on the tongue) without the need of water consumption. The electrospinning process and KIO3 loading did not alter the crystallinity and conformation of PEO. With high loading, KIO3 nanocrystals present in the fibers. This formulation design allows easy administration of iodine for preventing childhood iodine deficiency. It has also described a novel and easy method for producing and harvesting nanocrystals of inorganic salts that can be potentially adopted for use in other relevant fields.
Original languageEnglish
Pages (from-to)9831-9838
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume63
Issue number44
Early online date25 Oct 2015
DOIs
Publication statusPublished - 11 Nov 2015

Keywords

  • iodine deficiency
  • electrospinning
  • solid dispersions
  • nanocrystals
  • ultra-fast dissolving orodispersible film

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