Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure

P. Abraham, S. H. Ralston, M. Hewison, W. D. Fraser, J. S. Bevan

Research output: Contribution to journalArticle

38 Citations (Scopus)


Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.
Original languageEnglish
Pages (from-to)752-753
Number of pages2
JournalPostgraduate Medical Journal
Issue number926
Publication statusPublished - 2002

Cite this