Presentation of childhood CNS tumours: a systematic review and meta-analysis

Sophie Wilne, Jacqueline Collier, Colin Kennedy, Karin Koller, Richard Grundy, David Walker

Research output: Contribution to journalArticlepeer-review

286 Citations (Scopus)


Suspicion of a CNS tumour is classically raised by symptoms of raised intracranial pressure, focal deficits (including seizures), or papilloedema. Development of guidelines is needed for the identification and referral of children who might have a CNS tumour. We did a systematic literature review and meta-analysis to identify the clinical presentation of childhood CNS tumours to provide evidence to support the development of guidelines to assist with the identification and referral for imaging of children who might have a central nervous system tumour.
Original languageEnglish
Pages (from-to)685-695
Number of pages11
JournalThe Lancet Oncology
Issue number8
Publication statusPublished - Aug 2007


  • Central Nervous System Neoplasms
  • Child
  • Child Behavior Disorders
  • Headache
  • Humans
  • Neuropsychological Tests
  • Unconsciousness
  • Vision Disorders
  • Vomiting

Cite this