Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes

Gilles Montalescot; Leonardo Bolognese; Dariusz Dudek; Patrick Goldstein; Christian Hamm; Jean-Francois Tanguay; Jurrien M ten Berg; Debra L Miller; Timothy M Costigan; Jochen Goedicke; Johanne Silvain; Paolo Angioli; Jacek Legutko; Margit Niethammer; Zuzana Motovska; Joseph A Jakubowski; Guillaume Cayla; Luigi Oltrona Visconti; Eric Vicaut; Petr Widimsky; ACCOAST Investigators

doi:10.1056/NEJMoa1308075

Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes

Gilles Montalescot, Leonardo Bolognese, Dariusz Dudek, Patrick Goldstein, Christian Hamm, Jean-Francois Tanguay, Jurrien M ten Berg, Debra L Miller, Timothy M Costigan, Jochen Goedicke, Johanne Silvain, Paolo Angioli, Jacek Legutko, Margit Niethammer, Zuzana Motovska, Joseph A Jakubowski, Guillaume Cayla, Luigi Oltrona Visconti, Eric Vicaut, Petr WidimskyACCOAST Investigators

Research output: Contribution to journal › Article › peer-review

521 Citations (Scopus)

Abstract

Although P2Y12 antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated.

Original language	English
Pages (from-to)	999-1010
Number of pages	12
Journal	New England Journal of Medicine
Volume	369
Issue number	11
DOIs	https://doi.org/10.1056/NEJMoa1308075
Publication status	Published - 12 Sep 2013

Keywords

Double-Blind Method
Coronary Angiography
Humans
Percutaneous Coronary Intervention
Aged
Thiophenes
Hemorrhage
Piperazines
Premedication
Acute Coronary Syndrome
Coronary Artery Bypass
Purinergic P2Y Receptor Antagonists
Middle Aged
Myocardial Infarction
Female
Male

Access to Document

10.1056/NEJMoa1308075

Cite this

Montalescot, G., Bolognese, L., Dudek, D., Goldstein, P., Hamm, C., Tanguay, J-F., ten Berg, J. M., Miller, D. L., Costigan, T. M., Goedicke, J., Silvain, J., Angioli, P., Legutko, J., Niethammer, M., Motovska, Z., Jakubowski, J. A., Cayla, G., Visconti, L. O., Vicaut, E., ... ACCOAST Investigators (2013). Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. New England Journal of Medicine, 369(11), 999-1010. https://doi.org/10.1056/NEJMoa1308075

Montalescot, Gilles ; Bolognese, Leonardo ; Dudek, Dariusz ; Goldstein, Patrick ; Hamm, Christian ; Tanguay, Jean-Francois ; ten Berg, Jurrien M ; Miller, Debra L ; Costigan, Timothy M ; Goedicke, Jochen ; Silvain, Johanne ; Angioli, Paolo ; Legutko, Jacek ; Niethammer, Margit ; Motovska, Zuzana ; Jakubowski, Joseph A ; Cayla, Guillaume ; Visconti, Luigi Oltrona ; Vicaut, Eric ; Widimsky, Petr ; ACCOAST Investigators. / Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. In: New England Journal of Medicine. 2013 ; Vol. 369, No. 11. pp. 999-1010.

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title = "Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes",

abstract = "Although P2Y12 antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated.",

keywords = "Double-Blind Method, Coronary Angiography, Humans, Percutaneous Coronary Intervention, Aged, Thiophenes, Hemorrhage, Piperazines, Premedication, Acute Coronary Syndrome, Coronary Artery Bypass, Purinergic P2Y Receptor Antagonists, Middle Aged, Myocardial Infarction, Female, Male",

author = "Gilles Montalescot and Leonardo Bolognese and Dariusz Dudek and Patrick Goldstein and Christian Hamm and Jean-Francois Tanguay and {ten Berg}, {Jurrien M} and Miller, {Debra L} and Costigan, {Timothy M} and Jochen Goedicke and Johanne Silvain and Paolo Angioli and Jacek Legutko and Margit Niethammer and Zuzana Motovska and Jakubowski, {Joseph A} and Guillaume Cayla and Visconti, {Luigi Oltrona} and Eric Vicaut and Petr Widimsky and {ACCOAST Investigators} and Marcus Flather",

year = "2013",

month = sep,

day = "12",

doi = "10.1056/NEJMoa1308075",

language = "English",

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Montalescot, G, Bolognese, L, Dudek, D, Goldstein, P, Hamm, C, Tanguay, J-F, ten Berg, JM, Miller, DL, Costigan, TM, Goedicke, J, Silvain, J, Angioli, P, Legutko, J, Niethammer, M, Motovska, Z, Jakubowski, JA, Cayla, G, Visconti, LO, Vicaut, E, Widimsky, P & ACCOAST Investigators 2013, 'Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes', New England Journal of Medicine, vol. 369, no. 11, pp. 999-1010. https://doi.org/10.1056/NEJMoa1308075

Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. / Montalescot, Gilles; Bolognese, Leonardo; Dudek, Dariusz; Goldstein, Patrick; Hamm, Christian; Tanguay, Jean-Francois; ten Berg, Jurrien M; Miller, Debra L; Costigan, Timothy M; Goedicke, Jochen; Silvain, Johanne; Angioli, Paolo; Legutko, Jacek; Niethammer, Margit; Motovska, Zuzana; Jakubowski, Joseph A; Cayla, Guillaume; Visconti, Luigi Oltrona; Vicaut, Eric; Widimsky, Petr; ACCOAST Investigators.

In: New England Journal of Medicine, Vol. 369, No. 11, 12.09.2013, p. 999-1010.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes

AU - Montalescot, Gilles

AU - Bolognese, Leonardo

AU - Dudek, Dariusz

AU - Goldstein, Patrick

AU - Hamm, Christian

AU - Tanguay, Jean-Francois

AU - ten Berg, Jurrien M

AU - Miller, Debra L

AU - Costigan, Timothy M

AU - Goedicke, Jochen

AU - Silvain, Johanne

AU - Angioli, Paolo

AU - Legutko, Jacek

AU - Niethammer, Margit

AU - Motovska, Zuzana

AU - Jakubowski, Joseph A

AU - Cayla, Guillaume

AU - Visconti, Luigi Oltrona

AU - Vicaut, Eric

AU - Widimsky, Petr

AU - ACCOAST Investigators

AU - Flather, Marcus

PY - 2013/9/12

Y1 - 2013/9/12

N2 - Although P2Y12 antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated.

AB - Although P2Y12 antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated.

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KW - Coronary Angiography

KW - Humans

KW - Percutaneous Coronary Intervention

KW - Aged

KW - Thiophenes

KW - Hemorrhage

KW - Piperazines

KW - Premedication

KW - Acute Coronary Syndrome

KW - Coronary Artery Bypass

KW - Purinergic P2Y Receptor Antagonists

KW - Middle Aged

KW - Myocardial Infarction

KW - Female

KW - Male

U2 - 10.1056/NEJMoa1308075

DO - 10.1056/NEJMoa1308075

M3 - Article

C2 - 23991622

VL - 369

SP - 999

EP - 1010

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 11

ER -