Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

Jochen Springer, Anika Tschirner, Arash Haghikia, Stephan von Haehling, Hind Lal, Aleksandra Grzesiak, Elena Kaschina, Sandra Palus, Mareike Pötsch, Karoline von Websky, Berthold Hocher, Celine Latouche, Frederic Jaisser, Lars Morawietz, Andrew J S Coats, John Beadle, Josep M Argiles, Thomas Thum, Gabor Földes, Wolfram DoehnerDenise Hilfiker-Kleiner, Thomas Force, Stefan D Anker

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158 Citations (Scopus)


Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130).
Original languageEnglish
Pages (from-to)932-941
JournalEuropean Heart Journal
Issue number14
Early online date29 Aug 2013
Publication statusPublished - 2014

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