Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

Jochen Springer; Anika Tschirner; Arash Haghikia; Stephan von Haehling; Hind Lal; Aleksandra Grzesiak; Elena Kaschina; Sandra Palus; Mareike Pötsch; Karoline von Websky; Berthold Hocher; Celine Latouche; Frederic Jaisser; Lars Morawietz; Andrew J S Coats; John Beadle; Josep M Argiles; Thomas Thum; Gabor Földes; Wolfram Doehner; Denise Hilfiker-Kleiner; Thomas Force; Stefan D Anker

doi:10.1093/eurheartj/eht302

Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

Jochen Springer, Anika Tschirner, Arash Haghikia, Stephan von Haehling, Hind Lal, Aleksandra Grzesiak, Elena Kaschina, Sandra Palus, Mareike Pötsch, Karoline von Websky, Berthold Hocher, Celine Latouche, Frederic Jaisser, Lars Morawietz, Andrew J S Coats, John Beadle, Josep M Argiles, Thomas Thum, Gabor Földes, Wolfram DoehnerDenise Hilfiker-Kleiner, Thomas Force, Stefan D Anker

Research output: Contribution to journal › Article › peer-review

162 Citations (SciVal)

Abstract

Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130).

Original language	English
Pages (from-to)	932-941
Journal	European Heart Journal
Volume	35
Issue number	14
Early online date	29 Aug 2013
DOIs	https://doi.org/10.1093/eurheartj/eht302
Publication status	Published - 2014

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10.1093/eurheartj/eht302

Cite this

Springer, J., Tschirner, A., Haghikia, A., von Haehling, S., Lal, H., Grzesiak, A., Kaschina, E., Palus, S., Pötsch, M., von Websky, K., Hocher, B., Latouche, C., Jaisser, F., Morawietz, L., Coats, A. J. S., Beadle, J., Argiles, J. M., Thum, T., Földes, G., ... Anker, S. D. (2014). Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. European Heart Journal, 35(14), 932-941. https://doi.org/10.1093/eurheartj/eht302

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title = "Prevention of liver cancer cachexia-induced cardiac wasting and heart failure",

abstract = "Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130).",

author = "Jochen Springer and Anika Tschirner and Arash Haghikia and {von Haehling}, Stephan and Hind Lal and Aleksandra Grzesiak and Elena Kaschina and Sandra Palus and Mareike P{\"o}tsch and {von Websky}, Karoline and Berthold Hocher and Celine Latouche and Frederic Jaisser and Lars Morawietz and Coats, {Andrew J S} and John Beadle and Argiles, {Josep M} and Thomas Thum and Gabor F{\"o}ldes and Wolfram Doehner and Denise Hilfiker-Kleiner and Thomas Force and Anker, {Stefan D}",

year = "2014",

doi = "10.1093/eurheartj/eht302",

language = "English",

volume = "35",

pages = "932--941",

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publisher = "Oxford University Press",

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Springer, J, Tschirner, A, Haghikia, A, von Haehling, S, Lal, H, Grzesiak, A, Kaschina, E, Palus, S, Pötsch, M, von Websky, K, Hocher, B, Latouche, C, Jaisser, F, Morawietz, L, Coats, AJS, Beadle, J, Argiles, JM, Thum, T, Földes, G, Doehner, W, Hilfiker-Kleiner, D, Force, T & Anker, SD 2014, 'Prevention of liver cancer cachexia-induced cardiac wasting and heart failure', European Heart Journal, vol. 35, no. 14, pp. 932-941. https://doi.org/10.1093/eurheartj/eht302

TY - JOUR

T1 - Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

AU - Springer, Jochen

AU - Tschirner, Anika

AU - Haghikia, Arash

AU - von Haehling, Stephan

AU - Lal, Hind

AU - Grzesiak, Aleksandra

AU - Kaschina, Elena

AU - Palus, Sandra

AU - Pötsch, Mareike

AU - von Websky, Karoline

AU - Hocher, Berthold

AU - Latouche, Celine

AU - Jaisser, Frederic

AU - Morawietz, Lars

AU - Coats, Andrew J S

AU - Beadle, John

AU - Argiles, Josep M

AU - Thum, Thomas

AU - Földes, Gabor

AU - Doehner, Wolfram

AU - Hilfiker-Kleiner, Denise

AU - Force, Thomas

AU - Anker, Stefan D

PY - 2014

Y1 - 2014

N2 - Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130).

AB - Symptoms of cancer cachexia (CC) include fatigue, shortness of breath, and impaired exercise capacity, which are also hallmark symptoms of heart failure (HF). Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130).

U2 - 10.1093/eurheartj/eht302

DO - 10.1093/eurheartj/eht302

M3 - Article

C2 - 23990596

VL - 35

SP - 932

EP - 941

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 14

ER -