Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

Ildefonso Rodriguez Ramiro; Sonia Ramos; Laura Bravo; Luis Goya; Maria Ángeles Martín

doi:10.1007/s00394-011-0269-1

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

Ildefonso Rodriguez Ramiro, Sonia Ramos, Laura Bravo, Luis Goya, Maria Ángeles Martín

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved.

Original language	English
Pages (from-to)	881-892
Number of pages	12
Journal	European Journal of Nutrition
Volume	51
Issue number	7
DOIs	https://doi.org/10.1007/s00394-011-0269-1
Publication status	Published - 1 Oct 2012

Keywords

Antioxidants
Humans
Caco-2 Cells
Catechin
Reactive Oxygen Species
Extracellular Signal-Regulated MAP Kinases
Cell Survival
Biflavonoids
Glutathione S-Transferase pi
MAP Kinase Signaling System
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Proanthocyanidins
Oxidative Stress
Up-Regulation
Protein Transport
NF-E2-Related Factor 2
Cocoa flavonoids
Glutathione enzymes
Signalling pathways

Access to Document

10.1007/s00394-011-0269-1

Cite this

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title = "Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress",

abstract = "Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved.",

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author = "{Rodriguez Ramiro}, Ildefonso and Sonia Ramos and Laura Bravo and Luis Goya and Mart{\'i}n, {Maria {\'A}ngeles}",

year = "2012",

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doi = "10.1007/s00394-011-0269-1",

language = "English",

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journal = "European Journal of Nutrition",

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Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. / Rodriguez Ramiro, Ildefonso; Ramos, Sonia; Bravo, Laura et al.

In: European Journal of Nutrition, Vol. 51, No. 7, 01.10.2012, p. 881-892.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

AU - Rodriguez Ramiro, Ildefonso

AU - Ramos, Sonia

AU - Bravo, Laura

AU - Goya, Luis

AU - Martín, Maria Ángeles

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved.

AB - Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved.

KW - Antioxidants

KW - Humans

KW - Caco-2 Cells

KW - Catechin

KW - Reactive Oxygen Species

KW - Extracellular Signal-Regulated MAP Kinases

KW - Cell Survival

KW - Biflavonoids

KW - Glutathione S-Transferase pi

KW - MAP Kinase Signaling System

KW - p38 Mitogen-Activated Protein Kinases

KW - Phosphorylation

KW - Proanthocyanidins

KW - Oxidative Stress

KW - Up-Regulation

KW - Protein Transport

KW - NF-E2-Related Factor 2

KW - Cocoa flavonoids

KW - Glutathione enzymes

KW - Signalling pathways

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DO - 10.1007/s00394-011-0269-1

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JO - European Journal of Nutrition

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