Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

Ildefonso Rodriguez Ramiro, Sonia Ramos, Laura Bravo, Luis Goya, Maria Ángeles Martín

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118 Citations (Scopus)


Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved.
Original languageEnglish
Pages (from-to)881-892
Number of pages12
JournalEuropean Journal of Nutrition
Issue number7
Publication statusPublished - 1 Oct 2012


  • Antioxidants
  • Humans
  • Caco-2 Cells
  • Catechin
  • Reactive Oxygen Species
  • Extracellular Signal-Regulated MAP Kinases
  • Cell Survival
  • Biflavonoids
  • Glutathione S-Transferase pi
  • MAP Kinase Signaling System
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Proanthocyanidins
  • Oxidative Stress
  • Up-Regulation
  • Protein Transport
  • NF-E2-Related Factor 2
  • Cocoa flavonoids
  • Glutathione enzymes
  • Signalling pathways

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