Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

J Cuzick; Z H Yang; G Fisher; E Tikishvili; S Stone; J S Lanchbury; N Camacho; S Merson; D Brewer; C S Cooper; J Clark; D M Berney; H Møller; P Scardino; Z Sangale; Transatlantic Prostate Group

doi:10.1038/bjc.2013.248

Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

J Cuzick, Z H Yang, G Fisher, E Tikishvili, S Stone, J S Lanchbury, N Camacho, S Merson, D Brewer, C S Cooper, J Clark, D M Berney, H Møller, P Scardino, Z Sangale, Transatlantic Prostate Group

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

The natural history of prostate cancer is highly variable and difficult to predict. We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.

Original language	English
Pages (from-to)	2582-2589
Number of pages	8
Journal	British Journal of Cancer
Volume	108
Issue number	12
DOIs	https://doi.org/10.1038/bjc.2013.248
Publication status	Published - 25 Jun 2013

Keywords

Adenocarcinoma
Adult
Aged
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Ki-67 Antigen
Male
Middle Aged
Neoplasm Grading
PTEN Phosphohydrolase
Predictive Value of Tests
Prognosis
Prostate-Specific Antigen
Prostatic Neoplasms
Transurethral Resection of Prostate
Tumor Markers, Biological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/bjc.2013.248

Cite this

Cuzick, J., Yang, Z. H., Fisher, G., Tikishvili, E., Stone, S., Lanchbury, J. S., Camacho, N., Merson, S., Brewer, D., Cooper, C. S., Clark, J., Berney, D. M., Møller, H., Scardino, P., Sangale, Z., & Transatlantic Prostate Group (2013). Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer. British Journal of Cancer, 108(12), 2582-2589. https://doi.org/10.1038/bjc.2013.248

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title = "Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer",

abstract = "The natural history of prostate cancer is highly variable and difficult to predict. We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.",

keywords = "Adenocarcinoma, Adult, Aged, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Ki-67 Antigen, Male, Middle Aged, Neoplasm Grading, PTEN Phosphohydrolase, Predictive Value of Tests, Prognosis, Prostate-Specific Antigen, Prostatic Neoplasms, Transurethral Resection of Prostate, Tumor Markers, Biological",

author = "J Cuzick and Yang, {Z H} and G Fisher and E Tikishvili and S Stone and Lanchbury, {J S} and N Camacho and S Merson and D Brewer and Cooper, {C S} and J Clark and Berney, {D M} and H M{\o}ller and P Scardino and Z Sangale and {Transatlantic Prostate Group}",

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Cuzick, J, Yang, ZH, Fisher, G, Tikishvili, E, Stone, S, Lanchbury, JS, Camacho, N, Merson, S, Brewer, D , Cooper, CS , Clark, J, Berney, DM, Møller, H, Scardino, P, Sangale, Z & Transatlantic Prostate Group 2013, 'Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer', British Journal of Cancer, vol. 108, no. 12, pp. 2582-2589. https://doi.org/10.1038/bjc.2013.248

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T1 - Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

AU - Cuzick, J

AU - Yang, Z H

AU - Fisher, G

AU - Tikishvili, E

AU - Stone, S

AU - Lanchbury, J S

AU - Camacho, N

AU - Merson, S

AU - Brewer, D

AU - Cooper, C S

AU - Clark, J

AU - Berney, D M

AU - Møller, H

AU - Scardino, P

AU - Sangale, Z

AU - Transatlantic Prostate Group

PY - 2013/6/25

Y1 - 2013/6/25

N2 - The natural history of prostate cancer is highly variable and difficult to predict. We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.

AB - The natural history of prostate cancer is highly variable and difficult to predict. We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Gene Expression Regulation, Neoplastic

KW - Gene Silencing

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization, Fluorescence

KW - Ki-67 Antigen

KW - Male

KW - Middle Aged

KW - Neoplasm Grading

KW - PTEN Phosphohydrolase

KW - Predictive Value of Tests

KW - Prognosis

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Transurethral Resection of Prostate

KW - Tumor Markers, Biological

U2 - 10.1038/bjc.2013.248

DO - 10.1038/bjc.2013.248

M3 - Article

C2 - 23695019

VL - 108

SP - 2582

EP - 2589

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 12

ER -