Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

J Cuzick, Z H Yang, G Fisher, E Tikishvili, S Stone, J S Lanchbury, N Camacho, S Merson, D Brewer, C S Cooper, J Clark, D M Berney, H Møller, P Scardino, Z Sangale, Transatlantic Prostate Group

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

The natural history of prostate cancer is highly variable and difficult to predict. We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.
Original languageEnglish
Pages (from-to)2582-2589
Number of pages8
JournalBritish Journal of Cancer
Volume108
Issue number12
DOIs
Publication statusPublished - 25 Jun 2013

Keywords

  • Adenocarcinoma
  • Adult
  • Aged
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Ki-67 Antigen
  • Male
  • Middle Aged
  • Neoplasm Grading
  • PTEN Phosphohydrolase
  • Predictive Value of Tests
  • Prognosis
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Transurethral Resection of Prostate
  • Tumor Markers, Biological

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