Programmable polymer-DNA hydrogels with dual input and multiscale responses

Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernández-trillo, Sebastian G. Spain, Cameron Alexander

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.
Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalBiomaterials Science
Early online date4 Oct 2013
Publication statusPublished - 2014

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