Abstract
Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.
Original language | English |
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Pages (from-to) | 203-211 |
Number of pages | 9 |
Journal | Biomaterials Science |
Volume | 2 |
Early online date | 4 Oct 2013 |
DOIs | |
Publication status | Published - 2014 |