Programmable polymer-DNA hydrogels with dual input and multiscale responses

Giovanna Sicilia; Christine Grainger-Boultby; Nora Francini; Johannes P. Magnusson; Aram O. Saeed; Francisco Fernández-trillo; Sebastian G. Spain; Cameron Alexander

doi:10.1039/c3bm60126a

Programmable polymer-DNA hydrogels with dual input and multiscale responses

Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernández-trillo, Sebastian G. Spain, Cameron Alexander

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.

Original language	English
Pages (from-to)	203-211
Number of pages	9
Journal	Biomaterials Science
Volume	2
Early online date	4 Oct 2013
DOIs	https://doi.org/10.1039/c3bm60126a
Publication status	Published - 2014

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10.1039/c3bm60126a

Cite this

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abstract = "Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.",

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AU - Magnusson, Johannes P.

AU - Saeed, Aram O.

AU - Fernández-trillo, Francisco

AU - Spain, Sebastian G.

AU - Alexander, Cameron

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AB - Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.

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