Progression of lumbar disc degeneration over a decade: a heritability study

Frances M K Williams, Maria Popham, Philip N Sambrook, Annette F Jones, Tim D Spector, Alex J MacGregor, Alexander Macgregor

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors.
Original languageEnglish
Pages (from-to)1203-7
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Adult
  • Aged
  • Disease Progression
  • Diseases in Twins
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Intervertebral Disc Degeneration
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Phenotype
  • Twins, Dizygotic
  • Twins, Monozygotic

Cite this