Progression of lumbar disc degeneration over a decade: a heritability study

Frances M K Williams, Maria Popham, Philip N Sambrook, Annette F Jones, Tim D Spector, Alex J MacGregor, Alexander Macgregor

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors.
Original languageEnglish
Pages (from-to)1203-7
Number of pages5
JournalAnnals of the Rheumatic Diseases
Issue number7
Publication statusPublished - Jul 2011


  • Adult
  • Aged
  • Disease Progression
  • Diseases in Twins
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Intervertebral Disc Degeneration
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Phenotype
  • Twins, Dizygotic
  • Twins, Monozygotic

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