Progression of lumbar disc degeneration over a decade: a heritability study

Frances M K Williams; Maria Popham; Philip N Sambrook; Annette F Jones; Tim D Spector; Alex J MacGregor; Alexander Macgregor

doi:10.1136/ard.2010.146001

Progression of lumbar disc degeneration over a decade: a heritability study

Frances M K Williams, Maria Popham, Philip N Sambrook, Annette F Jones, Tim D Spector, Alex J MacGregor, Alexander Macgregor

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors.

Original language	English
Pages (from-to)	1203-7
Number of pages	5
Journal	Annals of the Rheumatic Diseases
Volume	70
Issue number	7
DOIs	https://doi.org/10.1136/ard.2010.146001
Publication status	Published - Jul 2011

Keywords

Adult
Aged
Disease Progression
Diseases in Twins
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Intervertebral Disc Degeneration
Lumbar Vertebrae
Magnetic Resonance Imaging
Male
Middle Aged
Phenotype
Twins, Dizygotic
Twins, Monozygotic

Access to Document

10.1136/ard.2010.146001

Cite this

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title = "Progression of lumbar disc degeneration over a decade: a heritability study",

abstract = "Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors.",

keywords = "Adult, Aged, Disease Progression, Diseases in Twins, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Intervertebral Disc Degeneration, Lumbar Vertebrae, Magnetic Resonance Imaging, Male, Middle Aged, Phenotype, Twins, Dizygotic, Twins, Monozygotic",

author = "Williams, {Frances M K} and Maria Popham and Sambrook, {Philip N} and Jones, {Annette F} and Spector, {Tim D} and MacGregor, {Alex J} and Alexander Macgregor",

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T2 - a heritability study

AU - Williams, Frances M K

AU - Popham, Maria

AU - Sambrook, Philip N

AU - Jones, Annette F

AU - Spector, Tim D

AU - MacGregor, Alex J

AU - Macgregor, Alexander

PY - 2011/7

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KW - Aged

KW - Disease Progression

KW - Diseases in Twins

KW - Female

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Intervertebral Disc Degeneration

KW - Lumbar Vertebrae

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Twins, Dizygotic

KW - Twins, Monozygotic

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DO - 10.1136/ard.2010.146001

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