Proliferating bipotential glial progenitor cells in adult rat optic nerve

Charles Ffrench-Constant, Martin C. Raff

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299 Citations (Scopus)

Abstract

We have shown previously that the rat optic nerve contains three types of macroglial cells - Oligodendrocytes and two types of astrocytes - Which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16)1, while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively 2. Here we report that proliferating bipotential oligoden-drocyte- type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalNature
Volume319
Issue number6053
DOIs
Publication statusPublished - 6 Feb 1986

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