Abstract
We have shown previously that the rat optic nerve contains three types of macroglial cells - Oligodendrocytes and two types of astrocytes - Which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16)1, while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively 2. Here we report that proliferating bipotential oligoden-drocyte- type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.
| Original language | English |
|---|---|
| Pages (from-to) | 499-502 |
| Number of pages | 4 |
| Journal | Nature |
| Volume | 319 |
| Issue number | 6053 |
| DOIs | |
| Publication status | Published - 6 Feb 1986 |