Proline 4-hydroxylase: Stereochemical course of the reaction

Jack E. Baldwin, Robert A. Field, Christopher C. Lawrence, Kirsten D. Merritt, Christopher J. Schofield

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Abstract

The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.

Original languageEnglish
Pages (from-to)7489-7492
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number46
DOIs
Publication statusPublished - 12 Nov 1993

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