Proline 4-hydroxylase: Stereochemical course of the reaction

Jack E. Baldwin; Robert A. Field; Christopher C. Lawrence; Kirsten D. Merritt; Christopher J. Schofield

doi:10.1016/S0040-4039(00)60161-2

Proline 4-hydroxylase: Stereochemical course of the reaction

Jack E. Baldwin, Robert A. Field, Christopher C. Lawrence, Kirsten D. Merritt, Christopher J. Schofield

School of Chemistry, Pharmacy and Pharmacology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-²H₁]-proline and (2S, 4R)-[4-²H₁]-proline and found to occur with retention of stereochemistry at C-4 of proline.

Original language	English
Pages (from-to)	7489-7492
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(00)60161-2
Publication status	Published - 12 Nov 1993

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title = "Proline 4-hydroxylase: Stereochemical course of the reaction",

abstract = "The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.",

author = "Baldwin, {Jack E.} and Field, {Robert A.} and Lawrence, {Christopher C.} and Merritt, {Kirsten D.} and Schofield, {Christopher J.}",

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AU - Baldwin, Jack E.

AU - Field, Robert A.

AU - Lawrence, Christopher C.

AU - Merritt, Kirsten D.

AU - Schofield, Christopher J.

PY - 1993/11/12

Y1 - 1993/11/12

N2 - The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.

AB - The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.

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U2 - 10.1016/S0040-4039(00)60161-2

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M3 - Article

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VL - 34

SP - 7489

EP - 7492

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Proline 4-hydroxylase: Stereochemical course of the reaction

Abstract

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