Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

R A Anderson, L M Evans, G R Ellis, N Khan, K Morris, S K Jackson, A Rees, M J Lewis, M P Frenneaux

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59 Citations (Scopus)

Abstract

Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.
Original languageEnglish
Pages (from-to)258-64
Number of pages7
JournalDiabetic Medicine
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Administration, Oral
  • Adult
  • Aged
  • Antioxidants
  • Area Under Curve
  • Ascorbic Acid
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Diabetes Mellitus, Type 2
  • Dietary Fats
  • Endothelium
  • Female
  • Humans
  • Lipid Peroxidation
  • Lipids
  • Lipoproteins, VLDL
  • Male
  • Middle Aged
  • Oxidative Stress
  • Postprandial Period
  • Triglycerides
  • Vasodilation

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