Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

R A Anderson; L M Evans; G R Ellis; N Khan; K Morris; S K Jackson; A Rees; M J Lewis; M P Frenneaux

doi:10.1111/j.1464-5491.2005.01767.x

Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

R A Anderson, L M Evans, G R Ellis, N Khan, K Morris, S K Jackson, A Rees, M J Lewis, M P Frenneaux

Research output: Contribution to journal › Article › peer-review

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Abstract

Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.

Original language	English
Pages (from-to)	258-64
Number of pages	7
Journal	Diabetic Medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1111/j.1464-5491.2005.01767.x
Publication status	Published - Mar 2006

Keywords

Administration, Oral
Adult
Aged
Antioxidants
Area Under Curve
Ascorbic Acid
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus, Type 2
Dietary Fats
Endothelium
Female
Humans
Lipid Peroxidation
Lipids
Lipoproteins, VLDL
Male
Middle Aged
Oxidative Stress
Postprandial Period
Triglycerides
Vasodilation

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Access to Document

10.1111/j.1464-5491.2005.01767.x

Cite this

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title = "Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes",

abstract = "Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.",

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author = "Anderson, {R A} and Evans, {L M} and Ellis, {G R} and N Khan and K Morris and Jackson, {S K} and A Rees and Lewis, {M J} and Frenneaux, {M P}",

year = "2006",

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language = "English",

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T1 - Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

AU - Anderson, R A

AU - Evans, L M

AU - Ellis, G R

AU - Khan, N

AU - Morris, K

AU - Jackson, S K

AU - Rees, A

AU - Lewis, M J

AU - Frenneaux, M P

PY - 2006/3

Y1 - 2006/3

N2 - Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.

AB - Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Antioxidants

KW - Area Under Curve

KW - Ascorbic Acid

KW - Cholesterol, HDL

KW - Cholesterol, LDL

KW - Diabetes Mellitus, Type 2

KW - Dietary Fats

KW - Endothelium

KW - Female

KW - Humans

KW - Lipid Peroxidation

KW - Lipids

KW - Lipoproteins, VLDL

KW - Male

KW - Middle Aged

KW - Oxidative Stress

KW - Postprandial Period

KW - Triglycerides

KW - Vasodilation

U2 - 10.1111/j.1464-5491.2005.01767.x

DO - 10.1111/j.1464-5491.2005.01767.x

M3 - Article

C2 - 16492208

VL - 23

SP - 258

EP - 264

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 3

ER -