Proteases of Trypanosoma brucei

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Human African trypanosomiasis (HAT) or sleeping sickness is a parasitic infection
caused by the protozoan Trypanosoma brucei. The disease occurs in sub-Saharan Africa where it is a major cause of morbidity and mortality in man. Combinations of toxicity and poor efficacy of current anti-sleeping sickness drugs means that new, effective, and better tolerated chemotherapies are needed for the treatment of human African trypanosomiasis. Proteases play a key role in the life cycle of T. brucei and in the pathogenesis of sleeping sickness. In vitro and in vivo studies over the last decades have shown that proteases are valid targets for the development of new drugs against T. brucei. Here, the major proteases of T. brucei and their cellular roles and potential as drug targets will be reviewed.
Original languageEnglish
Title of host publicationTrypanosomatid Diseases: Molecular Routes to Drug Discovery
EditorsT. Jäger, O. Koch, L. Flohé
Place of PublicationWeinheim
Number of pages18
Publication statusPublished - 2013

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