Projects per year
This study’s primary objective is to validate the 4AT against a reference standard. Secondary objectives include (a) comparing the 4AT with another widely used test (the Confusion Assessment Method (CAM)); b) determining if the 4AT is sensitive for general cognitive impairment; c) assessing if 4AT scores predict outcomes; including d) a health economic analysis.
Methods and analysis: 900 patients aged 70 or over in Emergency Departments or acute general medical wards will be recruited in three sites (Edinburgh, Bradford, Sheffield) over 18 months. Each patient will undergo a reference standard delirium assessment and will be randomised to assessment with either the 4AT or the CAM. At 12 weeks outcomes (length of stay, institutionalisation, and mortality) and resource utilisation will be collected by a questionnaire, and via the electronic patient record.
Ethics and dissemination: Ethical approval was granted in Scotland (Scotland A NHS Research Ethics Committee) and England (Yorkshire and the Humber NHS Research Ethics Committee). The study involves administering tests commonly used in clinical practice. The main ethical issues are the essential recruitment of people without capacity. Dissemination is planned via publication in high impact journals, presentation at conferences, social media and the website www.the4AT.com.
Registration details: International standard randomised controlled trial number (ISRCTN) 53388093. UK Clinical Research Network ID: 19502
- 1 Finished