Protonation of a subsite analogue of [FeFe]-hydrogenase: mechanism of a deceptively simple reaction revealed by time-resolved IR spectroscopy

Joseph A Wright; Christopher J Pickett

doi:10.1039/B912499C

Protonation of a subsite analogue of [FeFe]-hydrogenase: mechanism of a deceptively simple reaction revealed by time-resolved IR spectroscopy

Joseph A Wright, Christopher J Pickett

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We provide the first detailed time-resolved mechanistic information on the protonation of a model of the subsite of [FeFe]-hydrogenase, [Fe₂(µ-pdt)(CO)₄(PMe₃)₂]; the deceptively simple stoichiometric reaction is shown to be limited by the rate of protonation of the basal–apical isomer followed by its rearrangement to the transoid basal form.

Original language	English
Pages (from-to)	5719-5721
Number of pages	3
Journal	Chemical Communications
Issue number	38
DOIs	https://doi.org/10.1039/B912499C
Publication status	Published - 2009

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10.1039/B912499C

Cite this

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title = "Protonation of a subsite analogue of [FeFe]-hydrogenase: mechanism of a deceptively simple reaction revealed by time-resolved IR spectroscopy",

abstract = "We provide the first detailed time-resolved mechanistic information on the protonation of a model of the subsite of [FeFe]-hydrogenase, [Fe2(µ-pdt)(CO)4(PMe3)2]; the deceptively simple stoichiometric reaction is shown to be limited by the rate of protonation of the basal–apical isomer followed by its rearrangement to the transoid basal form.",

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AU - Pickett, Christopher J

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AB - We provide the first detailed time-resolved mechanistic information on the protonation of a model of the subsite of [FeFe]-hydrogenase, [Fe2(µ-pdt)(CO)4(PMe3)2]; the deceptively simple stoichiometric reaction is shown to be limited by the rate of protonation of the basal–apical isomer followed by its rearrangement to the transoid basal form.

U2 - 10.1039/B912499C

DO - 10.1039/B912499C

M3 - Article

SN - 1364-548X

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JO - Chemical Communications

JF - Chemical Communications

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