Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

German E. Berrios; A. C. Wagle; Ivana S. Marková; S. A. Wagle; Luk W. Ho; David C. Rubinsztein; Joanne Whittaker; Charles ffrench-Constant; Ann Kershaw; Anne Rosser; Thomas Bak; John R. Hodges

doi:10.1016/S0165-1781(01)00257-8

Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

German E. Berrios, A. C. Wagle, Ivana S. Marková, S. A. Wagle, Luk W. Ho, David C. Rubinsztein, Joanne Whittaker, Charles ffrench-Constant, Ann Kershaw, Anne Rosser, Thomas Bak, John R. Hodges

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systoms and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.

Original language	English
Pages (from-to)	217-225
Number of pages	9
Journal	Psychiatry Research
Volume	102
Issue number	3
DOIs	https://doi.org/10.1016/S0165-1781(01)00257-8
Publication status	Published - 24 Jul 2001

Keywords

Age of onset
Cognition
Genetics
Irritability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-1781(01)00257-8

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Berrios, G. E., Wagle, A. C., Marková, I. S., Wagle, S. A., Ho, L. W., Rubinsztein, D. C., Whittaker, J., ffrench-Constant, C., Kershaw, A., Rosser, A., Bak, T., & Hodges, J. R. (2001). Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Research, 102(3), 217-225. https://doi.org/10.1016/S0165-1781(01)00257-8

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abstract = "The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systoms and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.",

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AU - Berrios, German E.

AU - Wagle, A. C.

AU - Marková, Ivana S.

AU - Wagle, S. A.

AU - Ho, Luk W.

AU - Rubinsztein, David C.

AU - Whittaker, Joanne

AU - ffrench-Constant, Charles

AU - Kershaw, Ann

AU - Rosser, Anne

AU - Bak, Thomas

AU - Hodges, John R.

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AB - The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systoms and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.

KW - Age of onset

KW - Cognition

KW - Genetics

KW - Irritability

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Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

Abstract

Keywords

UN SDGs

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