Quality of life (QOL) in the context of education is an understudied topic and research related to its’ relation to the sense of coherence (SOC), level of optimism (LOO) and self-efficacy (SE) among students seems to be missing. The rationale for this survey was to fill this gap in knowledge and therefore, the aim of the study is to examine the relationship between students’ QOL and psychological variables such as SOC, LOO and SE, and social ones such as type of faculty, students’ social background and sex. The quantitative cross sectional survey has been conducted at three higher education institutions in Poland in January 2006. The random sample of 396 undergraduate students (average age was 20.5 years) representing 5 different faculties namely physiotherapy, physical education, tourism and recreation, English and Polish philology has been selected and participated in the study. Four reliable and validated research tools have been used to collect the data. These included the SF-36, SOC-29, Seligman’s scale, and GSES. The results have shown to indicate that different variables had a significant effect on particular subscales of the QOL outcomes. For example, among social variables faculty had a significant effect on physical functioning, role limitation due to physical functioning, and changes in health. Sex had a significant effect on role limitation due to emotional problems, social functioning, and energy vitality. Social background had a significant effect on general health. Among psychological variables the sense of coherence was significantly related to all subscales of QOL. A significant effect was noted by self-efficacy on physical and social functioning. Level of optimism had a significant effect on energy-vitality and general health. This research survey has suggested that changes in academic curriculum might be implemented to improve students QOL.