Psychotic-like experiences with cannabis use predict cannabis cessation and desire to quit- A cannabis discontinuation hypothesis

Musa Sami (Lead Author), Caitlin Notley, Christos Kouimtsidis, Michael Lynskey, Sagnik Bhattacharyya (Lead Author)

Research output: Contribution to journalArticlepeer-review

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Background Evidence suggests that cannabis-induced psychotic-like experiences may be a marker of psychosis proneness. The effect of such experiences on cannabis use has not systematically been examined.Methods We undertook a mixed-methods online survey of 1231 cannabis users (including 926 continued users) using the Cannabis Experiences Questionnaire. We examined the effect of psychotic-like and pleasurable experiences on cessation of cannabis and intention to quit. Socio-demographic variables, cannabis use parameters and substance misuse history were included as covariates. Free-text data explored subjective reasons for changes in use.Results Cessation of cannabis use was associated with greater psychotic-like experiences [p < 0.001, Exp(B) 1.262, 95% confidence interval (CI) 1.179-1.351], whilst continued cannabis users were more likely to report pleasurable experiences [p < 0.001, Exp(B) 0.717, 95% CI 0.662-0.776]. Intention to quit cannabis in continued users was associated with greater psychotic-like experiences [p < 0.003, Exp(B) 1.131, 95% CI 1.044-1.225], whilst intention to not quit was significantly associated with increased pleasurable experiences [p < 0.015, Exp(B) 0.892, 95% CI 0.814-0.978]. Whereas former users clearly ascribed cessation to negative experiences, continued users who expressed intention to quit less readily ascribed the intention to negative experiences.Conclusions Elucidation of psychotic-like experiences may form the basis of a therapeutic intervention for those who wish to quit. Cessation in those with cannabis-induced psychotomimetic experiences may offset the risk for the development of a psychotic disorder, in this higher risk group.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalPsychological Medicine
Issue number1
Early online date23 Mar 2018
Publication statusPublished - Jan 2019


  • Cannabis
  • cessation
  • discontinuation
  • marijuana
  • pattern of use
  • psychosis risk
  • psychotic-like experiences

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