PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D White, Aftab M Ahmad, Brian H Durham, Rajesh Peter, V Karthik B Prabhakar, Pamela Corlett, Jiten P Vora, WD Fraser

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AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.
Original languageEnglish
Pages (from-to)1798-1807
Number of pages10
JournalJournal of Bone and Mineral Research
Issue number11
Publication statusPublished - Nov 2007

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