PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D White; Aftab M Ahmad; Brian H Durham; Rajesh Peter; V Karthik B Prabhakar; Pamela Corlett; Jiten P Vora; WD Fraser

doi:10.1359/jbmr.070715

PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D White, Aftab M Ahmad, Brian H Durham, Rajesh Peter, V Karthik B Prabhakar, Pamela Corlett, Jiten P Vora, WD Fraser

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

Original language	English
Pages (from-to)	1798-1807
Number of pages	10
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	11
DOIs	https://doi.org/10.1359/jbmr.070715
Publication status	Published - Nov 2007

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10.1359/jbmr.070715

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@article{b22c156880c641648789a037d75fe27f,

title = "PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD",

abstract = "AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.",

author = "White, {Helen D} and Ahmad, {Aftab M} and Durham, {Brian H} and Rajesh Peter and Prabhakar, {V Karthik B} and Pamela Corlett and Vora, {Jiten P} and WD Fraser",

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PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD. / White, Helen D; Ahmad, Aftab M; Durham, Brian H; Peter, Rajesh; Prabhakar, V Karthik B; Corlett, Pamela; Vora, Jiten P; Fraser, WD.

In: Journal of Bone and Mineral Research, Vol. 22, No. 11, 11.2007, p. 1798-1807.

Research output: Contribution to journal › Article

TY - JOUR

T1 - PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

AU - White, Helen D

AU - Ahmad, Aftab M

AU - Durham, Brian H

AU - Peter, Rajesh

AU - Prabhakar, V Karthik B

AU - Corlett, Pamela

AU - Vora, Jiten P

AU - Fraser, WD

PY - 2007/11

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N2 - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

AB - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

U2 - 10.1359/jbmr.070715

DO - 10.1359/jbmr.070715

M3 - Article

VL - 22

SP - 1798

EP - 1807

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 11

ER -