PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D. White; Aftab M. Ahmad; Brian H. Durham; Rajesh Peter; V. Karthik B. Prabhakar; Pamela Corlett; Jiten P. Vora; William D. Fraser

doi:10.1359/jbmr.070715

PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D. White, Aftab M. Ahmad, Brian H. Durham, Rajesh Peter, V. Karthik B. Prabhakar, Pamela Corlett, Jiten P. Vora, William D. Fraser

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19 Citations (Scopus)

Abstract

AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

Original language	English
Pages (from-to)	1798-1807
Number of pages	10
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	11
DOIs	https://doi.org/10.1359/jbmr.070715
Publication status	Published - 1 Nov 2007

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10.1359/jbmr.070715

Cite this

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title = "PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD",

abstract = "AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.",

author = "White, {Helen D.} and Ahmad, {Aftab M.} and Durham, {Brian H.} and Rajesh Peter and Prabhakar, {V. Karthik B.} and Pamela Corlett and Vora, {Jiten P.} and Fraser, {William D.}",

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T1 - PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

AU - White, Helen D.

AU - Ahmad, Aftab M.

AU - Durham, Brian H.

AU - Peter, Rajesh

AU - Prabhakar, V. Karthik B.

AU - Corlett, Pamela

AU - Vora, Jiten P.

AU - Fraser, William D.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

AB - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

U2 - 10.1359/jbmr.070715

DO - 10.1359/jbmr.070715

M3 - Article

VL - 22

SP - 1798

EP - 1807

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 11

ER -