PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D. White; Aftab M. Ahmad; Brian H. Durham; Rajesh Peter; V. Karthik B. Prabhakar; Pamela Corlett; Jiten P. Vora; William D. Fraser

doi:10.1359/jbmr.070715

PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

Helen D. White
, Aftab M. Ahmad
, Brian H. Durham
, Rajesh Peter
, V. Karthik B. Prabhakar
, Pamela Corlett
, Jiten P. Vora
, William D. Fraser

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

Original language	English
Pages (from-to)	1798-1807
Number of pages	10
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	11
DOIs	https://doi.org/10.1359/jbmr.070715
Publication status	Published - 1 Nov 2007

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10.1359/jbmr.070715

Cite this

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title = "PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD",

abstract = "AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.",

author = "White, \{Helen D.\} and Ahmad, \{Aftab M.\} and Durham, \{Brian H.\} and Rajesh Peter and Prabhakar, \{V. Karthik B.\} and Pamela Corlett and Vora, \{Jiten P.\} and Fraser, \{William D.\}",

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AU - White, Helen D.

AU - Ahmad, Aftab M.

AU - Durham, Brian H.

AU - Peter, Rajesh

AU - Prabhakar, V. Karthik B.

AU - Corlett, Pamela

AU - Vora, Jiten P.

AU - Fraser, William D.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

AB - AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

U2 - 10.1359/jbmr.070715

DO - 10.1359/jbmr.070715

M3 - Article

SN - 1523-4681

VL - 22

SP - 1798

EP - 1807

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 11

ER -