Pulsation modes and the effect of applied voltage on current and flow rate in nanoelectrospray

Matthew S. Alexander, Mark D. Paine, John P. W. Stark

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.
Original languageEnglish
Pages (from-to)2658-2664
Number of pages7
JournalAnalytical Chemistry
Issue number8
Early online date25 Feb 2006
Publication statusPublished - 1 Apr 2006

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