Pulsation modes and the effect of applied voltage on current and flow rate in nanoelectrospray

Matthew S. Alexander; Mark D. Paine; John P. W. Stark

doi:10.1021/ac0520036

Pulsation modes and the effect of applied voltage on current and flow rate in nanoelectrospray

Matthew S. Alexander, Mark D. Paine, John P. W. Stark

School of Education & Lifelong Learning

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.

Original language	English
Pages (from-to)	2658-2664
Number of pages	7
Journal	Analytical Chemistry
Volume	78
Issue number	8
Early online date	25 Feb 2006
DOIs	https://doi.org/10.1021/ac0520036
Publication status	Published - 1 Apr 2006

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10.1021/ac0520036

Cite this

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abstract = "New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.",

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N2 - New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.

AB - New modes of nanoelectrospray (nES) have been identified that exhibit stable high-frequency current oscillations in the kilohertz range. In-line flow rate measurements during nES have for the first time allowed the accurate determination of the spray current and volumetric flow rate dependence on applied voltage. High-speed video imaging has revealed that each current pulse corresponds to the periodic formation of a short-lived stable cone-jet structure at the capillary tip. These findings are of particular importance and suggest greater process monitoring and control in nES-MS systems is necessary if efficiency and ion yield are to be optimized.

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