Purinergic P2X Receptors as Therapeutic Targets

Leanne Stokes, Stefan Bidula, Ronald Sluyter

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.

Original languageEnglish
Title of host publicationIon Channels as Targets in Drug Discovery
PublisherSpringer
Pages439-460
Number of pages22
ISBN (Electronic)9783031521973
ISBN (Print)9783031521966
DOIs
Publication statusPublished - 25 Apr 2024

Keywords

  • Cancer
  • Chronic cough
  • Inflammatory disorders
  • P2X
  • Pain disorders
  • Psychiatric disorders
  • Purinergic receptors

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