Purinergic P2X Receptors as Therapeutic Targets

Leanne Stokes; Stefan Bidula; Ronald Sluyter

doi:10.1007/978-3-031-52197-3_13

Purinergic P2X Receptors as Therapeutic Targets

Leanne Stokes
, Stefan Bidula
, Ronald Sluyter

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.

Original language	English
Title of host publication	Ion Channels as Targets in Drug Discovery
Publisher	Springer
Pages	439-460
Number of pages	22
ISBN (Electronic)	9783031521973
ISBN (Print)	9783031521966
DOIs	https://doi.org/10.1007/978-3-031-52197-3_13
Publication status	Published - 25 Apr 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Chronic cough
Inflammatory disorders
P2X
Pain disorders
Psychiatric disorders
Purinergic receptors

Access to Document

10.1007/978-3-031-52197-3_13

Cite this

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abstract = "Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.",

keywords = "Cancer, Chronic cough, Inflammatory disorders, P2X, Pain disorders, Psychiatric disorders, Purinergic receptors",

author = "Leanne Stokes and Stefan Bidula and Ronald Sluyter",

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T1 - Purinergic P2X Receptors as Therapeutic Targets

AU - Stokes, Leanne

AU - Bidula, Stefan

AU - Sluyter, Ronald

N1 - Publisher Copyright: © The Author(s), Springer Nature Switzerland AG 2024.

PY - 2024/4/25

Y1 - 2024/4/25

N2 - Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.

AB - Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.

KW - Cancer

KW - Chronic cough

KW - Inflammatory disorders

KW - P2X

KW - Pain disorders

KW - Psychiatric disorders

KW - Purinergic receptors

UR - https://www.scopus.com/pages/publications/85205360135

U2 - 10.1007/978-3-031-52197-3_13

DO - 10.1007/978-3-031-52197-3_13

M3 - Chapter

AN - SCOPUS:85205360135

SN - 9783031521966

SP - 439

EP - 460

BT - Ion Channels as Targets in Drug Discovery

PB - Springer

ER -

Purinergic P2X Receptors as Therapeutic Targets

Abstract

UN SDGs

Keywords

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