Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

J A Palanivel, A E Macbeth, N J Levell

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21 Citations (Scopus)

Abstract

Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalClinical and Experimental Dermatology
Volume38
Issue number1
Early online date21 May 2012
DOIs
Publication statusPublished - Jan 2013

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